Chemical Compound Review:
Ustekinumab 6,6-dimethyl-1-[3-(2,4,5...
Synonyms:
CHEMBL129788, BRL-6231, AG-F-01693, SureCN8635467, BRL-51084, ...
- Enhanced in vitro activity of WR99210 in combination with dapsone against Mycobacterium avium complex. Shah, L.M., DeStefano, M.S., Cynamon, M.H. Antimicrob. Agents Chemother. (1996)
- Triazine Inhibits Toxoplasma gondii tachyzoites in vitro and in vivo. Mui, E.J., Jacobus, D., Milhous, W.K., Schiehser, G., Hsu, H., Roberts, C.W., Kirisits, M.J., McLeod, R. Antimicrob. Agents Chemother. (2005)
- Analysis in yeast of antimalaria drugs that target the dihydrofolate reductase of Plasmodium falciparum. Wooden, J.M., Hartwell, L.H., Vasquez, B., Sibley, C.H. Mol. Biochem. Parasitol. (1997)
- Pyrimethamine and WR99210 exert opposing selection on dihydrofolate reductase from Plasmodium vivax. Hastings, M.D., Sibley, C.H. Proc. Natl. Acad. Sci. U.S.A. (2002)
- Transformation with human dihydrofolate reductase renders malaria parasites insensitive to WR99210 but does not affect the intrinsic activity of proguanil. Fidock, D.A., Wellems, T.E. Proc. Natl. Acad. Sci. U.S.A. (1997)
- In vitro metabolism of phenoxypropoxybiguanide analogues in human liver microsomes to potent antimalarial dihydrotriazines. Shearer, T.W., Kozar, M.P., O'Neil, M.T., Smith, P.L., Schiehser, G.A., Jacobus, D.P., Diaz, D.S., Yang, Y.S., Milhous, W.K., Skillman, D.R. J. Med. Chem. (2005)
- Novel alleles of the Plasmodium falciparum dhfr highly resistant to pyrimethamine and chlorcycloguanil, but not WR99210. Hankins, E.G., Warhurst, D.C., Sibley, C.H. Mol. Biochem. Parasitol. (2001)
- Improved transfection and new selectable markers for the rodent malaria parasite Plasmodium yoelii. Jongco, A.M., Ting, L.M., Thathy, V., Mota, M.M., Kim, K. Mol. Biochem. Parasitol. (2006)
- The selectable marker human dihydrofolate reductase enables sequential genetic manipulation of the Plasmodium berghei genome. de Koning-Ward, T.F., Fidock, D.A., Thathy, V., Menard, R., van Spaendonk, R.M., Waters, A.P., Janse, C.J. Mol. Biochem. Parasitol. (2000)
- An amino acid substitution in the Babesia bovis dihydrofolate reductase-thymidylate synthase gene is correlated to cross-resistance against pyrimethamine and WR99210. Gaffar, F.R., Wilschut, K., Franssen, F.F., de Vries, E. Mol. Biochem. Parasitol. (2004)
- Activity of PS-15 and its metabolite, WR99210, against Plasmodium falciparum in an in vivo-in vitro model. Rieckmann, K.H., Yeo, A.E., Edstein, M.D. Trans. R. Soc. Trop. Med. Hyg. (1996)
- Three-dimensional structure of M. tuberculosis dihydrofolate reductase reveals opportunities for the design of novel tuberculosis drugs. Li, R., Sirawaraporn, R., Chitnumsub, P., Sirawaraporn, W., Wooden, J., Athappilly, F., Turley, S., Hol, W.G. J. Mol. Biol. (2000)
- In vitro activities of the biguanide PS-15 and its metabolite, WR99210, against cycloguanil-resistant Plasmodium falciparum isolates from Thailand. Edstein, M.D., Bahr, S., Kotecka, B., Shanks, G.D., Rieckmann, K.H. Antimicrob. Agents Chemother. (1997)
- PS-15: a potent, orally active antimalarial from a new class of folic acid antagonists. Canfield, C.J., Milhous, W.K., Ager, A.L., Rossan, R.N., Sweeney, T.R., Lewis, N.J., Jacobus, D.P. Am. J. Trop. Med. Hyg. (1993)
- Negative selection of Plasmodium falciparum reveals targeted gene deletion by double crossover recombination. Duraisingh, M.T., Triglia, T., Cowman, A.F. Int. J. Parasitol. (2002)
- Novel Saccharomyces cerevisiae screen identifies WR99210 analogues that inhibit Mycobacterium tuberculosis dihydrofolate reductase. Gerum, A.B., Ulmer, J.E., Jacobus, D.P., Jensen, N.P., Sherman, D.R., Sibley, C.H. Antimicrob. Agents Chemother. (2002)
- Evaluation of WR250417 (a proguanil analog) for causal prophylactic activity in the Plasmodium cynomolgi-Macaca mulatta model. Edstein, M.D., Corcoran, K.D., Shanks, G.D., Ngampochjana, M., Hansukjariya, P., Sattabongkot, J., Webster, H.K., Rieckmann, K.H. Am. J. Trop. Med. Hyg. (1994)
- Effects of folic and folinic acids in the activities of cycloguanil and WR99210 against Plasmodium falciparum in erythrocytic culture. Yeo, A.E., Seymour, K.K., Rieckmann, K.H., Christopherson, R.I. Ann. Trop. Med. Parasitol. (1997)