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Chemical Compound Review

Ips-339     1-(fluoren-9- ylideneamino)oxy-3-(tert...

Synonyms: IPS 339, AC1L3TIG, AR-1H5680, LS-177379, AC1Q3F4D, ...
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Psychiatry related information on 1-(fluoren-9-ylideneamino)oxy-3-(tert-butylamino)propan-2-ol

  • Intrathecally administered propranolol (1 and 5 micrograms per rat), atenolol (1 and 5 micrograms per rat) and IPS-339 (1 and 5 micrograms per rat) remarkably inhibited the increase of the response latency induced by MA (50 ng per rat) given into the NRPG [1].
 

High impact information on 1-(fluoren-9-ylideneamino)oxy-3-(tert-butylamino)propan-2-ol

  • Atenolol (1 mg/kg) attenuated significantly the decrease in myocardial pH that had been induced by partial occlusion, whereas IPS 339 (360 micrograms/kg) and ICI 118,551 (300 micrograms/kg) did not [2].
  • Isoproterenol elicited a significant renin release in the presence of beta-1 adrenoceptor blockade with atenolol and in the presence of selective beta-2 adrenoceptor blockade with IPS-339 [3].
  • 2 The present experiments examine the effects of a potent and highly specific beta 2-antagonist (IPS 339) on intraocular pressure in the normal rabbit eye [4].
  • Practolol and CGP 20712A (selective beta 1-adrenoceptor antagonists) displaced with high affinity from a greater proportion of sites than ICI 118,551 and IPS 339 (selective beta 2-adrenoceptor antagonists) [5].
  • Studies with a specific beta 2-antagonist, IPS 339, indicated that 72% of receptors present were of the beta 2-subtype [6].
 

Biological context of 1-(fluoren-9-ylideneamino)oxy-3-(tert-butylamino)propan-2-ol

 

Anatomical context of 1-(fluoren-9-ylideneamino)oxy-3-(tert-butylamino)propan-2-ol

 

Associations of 1-(fluoren-9-ylideneamino)oxy-3-(tert-butylamino)propan-2-ol with other chemical compounds

  • Propranolol, 2.5 mg/kg intraperitoneally, and the selective beta 2-receptor antagonist IPS 339, 5 mg/kg intraperitoneally, almost completely antagonized the effect of clenbuterol, 1 mg/kg intraperitoneally [12].
 

Gene context of 1-(fluoren-9-ylideneamino)oxy-3-(tert-butylamino)propan-2-ol

  • IPS 339, a selective antagonist of beta-2 adrenoceptors, also injected icv, reduced PRL secretion during stress in a dose dependent fashion [13].
 

Analytical, diagnostic and therapeutic context of 1-(fluoren-9-ylideneamino)oxy-3-(tert-butylamino)propan-2-ol

  • Intravenous injection of IPS-339 (0.03, 0.1 and 0.3 mg/kg), a selective beta-2 adrenoceptor antagonist, diminished the stimulation-induced increases in LV dp/dt max and coronary sinus blood flow in a dose-dependent manner, whereas it did not decrease the stimulation-induced increase in NE output [14].

References

  1. Mechanism of the antinociceptive action of mesaconitine: participation of brain stem and lumbar enlargement. Hikino, H., Murayama, M. Br. J. Pharmacol. (1985) [Pubmed]
  2. Attenuation by atenolol of myocardial acidosis during ischemia in dogs: contribution of beta-1 adrenoceptors to myocardial acidosis. Sakai, K., Abiko, Y. J. Pharmacol. Exp. Ther. (1985) [Pubmed]
  3. Beta adrenergically mediated release of renin in the dog is not confined to either beta-1 or beta-2 adrenoceptors. Olson, R.D., Nies, A.S., Gerber, J.G. J. Pharmacol. Exp. Ther. (1982) [Pubmed]
  4. Effects of a potent and specific beta 2-adrenoceptor antagonist on intraocular pressure. Nathanson, J.A. Br. J. Pharmacol. (1981) [Pubmed]
  5. Beta-adrenoceptors in human brain labelled with [3H]dihydroalprenolol and [3H]CGP 12177. De Paermentier, F., Cheetham, S.C., Crompton, M.R., Horton, R.W. Eur. J. Pharmacol. (1989) [Pubmed]
  6. Failure to demonstrate decreased beta-adrenergic receptor concentration or decreased agonist efficacy in term or preterm human parturition. Dattel, B.J., Lam, F., Roberts, J.M. Am. J. Obstet. Gynecol. (1986) [Pubmed]
  7. Regional myocardial tissue blood flow during beta-adrenergic blockade in cat hearts with acute ischaemia. Stangeland, L., Grong, K., Lekven, J. Clinical physiology (Oxford, England) (1984) [Pubmed]
  8. Regional myocardial tissue blood flow during sequential beta 1- and beta 2-adrenergic blockade in cat hearts with acute ischaemia. Grong, K., Stangeland, L., Lekven, J. Scand. J. Clin. Lab. Invest. (1983) [Pubmed]
  9. beta 1-and beta 2-adrenoceptor stimulatory effects of prenalterol. Mattsson, H., Andersson, T., Carlsson, E., Hedberg, A., Lundgren, B., Olsson, T. Naunyn Schmiedebergs Arch. Pharmacol. (1982) [Pubmed]
  10. How beta2-selective is the adrenoceptor antagonist drug, IPS 339? O'Donnell, S.R., Walduck, K. J. Pharm. Pharmacol. (1981) [Pubmed]
  11. The adrenoceptor blocking properties of the new beta 2-selective antagonist, IPS 339 on tracheal smooth muscle and on slow contracting skeletal muscle. Holmberg, E., Jeppsson, A.B., Lamm, C.J., Waldeck, B. Acta pharmacologica et toxicologica. (1980) [Pubmed]
  12. Antagonism of reserpine-induced hypothermia in mice by some beta-adrenoceptor agonists. Ross, S.B. Acta pharmacologica et toxicologica. (1980) [Pubmed]
  13. Role of central beta-adrenoceptors on stress-induced prolactin release in rats. Haanwinckel, M.A., Antunes-Rodrigues, J., De Castro e Silva, E. Horm. Metab. Res. (1991) [Pubmed]
  14. Effects of epinephrine, isoproterenol and IPS-339 on sympathetic transmission to the dog heart: evidence against the facilitatory role of presynaptic beta adrenoceptors. Yorikane, R., Kanda, A., Kimura, T., Satoh, S. J. Pharmacol. Exp. Ther. (1986) [Pubmed]
 
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