Chemical Compound Review:
Dacopafant 8-pyridin-3-yl-7-thia-1...
Synonyms:
CHEMBL67588, AG-H-81484, SureCN9376223, AC1L3TJS, RP-48740, ...
- A platelet-activating factor antagonist, RP 55778, inhibits cytokine-dependent induction of human immunodeficiency virus expression in chronically infected promonocytic cells. Weissman, D., Poli, G., Bousseau, A., Fauci, A.S. Proc. Natl. Acad. Sci. U.S.A. (1993)
- Infection of human macrophages with an endogenous tumour necrosis factor-alpha (TNF-alpha)-independent human immunodeficiency virus type 1 isolate is unresponsive to the TNF-alpha synthesis inhibitor RP 55778. Le Naour, R., Clayette, P., Henin, Y., Mabondzo, A., Raoul, H., Bousseau, A., Dormont, D. J. Gen. Virol. (1994)
- Intravenous injections of PAF-acether induce platelet aggregation in rats. Martins, M.A., Martins, P.M., Faria Neto, H.C., Bozza, P.T., Dias, P.M., Cordeiro, R.S., Vargaftig, B.B. Eur. J. Pharmacol. (1988)
- A PAF-acether antagonist (N 48740 RP/Rhône-Poulenc) and laser-induced thrombi in rat mesenteric vessels. Weichert, W., Breddin, H.K. Haemostasis (1989)
- RP 55778, a PAF receptor antagonist, prevents and reverses LPS-induced hemoconcentration and TNF release. Floch, A., Bousseau, A., Hetier, E., Floc'h, F., Bost, P.E., Cavero, I. Journal of lipid mediators. (1989)
- Human endothelial cells are target for platelet-activating factor. I. Platelet-activating factor induces changes in cytoskeleton structures. Bussolino, F., Camussi, G., Aglietta, M., Braquet, P., Bosia, A., Pescarmona, G., Sanavio, F., D'Urso, N., Marchisio, P.C. J. Immunol. (1987)
- Effects of RP 55778, a tumor necrosis factor alpha synthesis inhibitor, on antiviral activity of dideoxynucleosides. Clayette, P., Dereuddre-Bosquet, N., Martin, M., Fretier, P., Dormont, D. Antimicrob. Agents Chemother. (1997)
- Prolonged survival of renal transplants in nonimmunized and hyperimmunized rats receiving a platelet-activating factor antagonist. Freiche, J.C., Lang, J., Sedivy, P., Touraine, J.L. Transplantation (1990)
- Platelet mobilization induced by PAF and its role in the thrombocytosis triggered by adrenaline in rats. Castro-Faria-Neto, H.C., Bozza, P.T., Martins, M.A., Dias, P.M., Silva, P.M., Cordeiro, R.S. Thromb. Haemost. (1989)
- Inhibition of ex-vivo PAF-induced platelet aggregation by the PAF-antagonist RP 48740: relationship to plasma concentrations in healthy volunteers. Pinquier, J.L., Sedivy, P., Bruno, R., Bompart, F., Gregoire, J., Strauch, G., Gaillot, J., Clucas, A. Eur. J. Clin. Pharmacol. (1991)
- 48740 RP, an antagonist of PAF, does not affect human plasma fibrinolysis before and after venous occlusion. Hanss, M., Dechavanne, M. Thromb. Res. (1988)
- Modulation of pulmonary inflammation after endotoxin inhalation with a platelet-activating factor antagonist (48740 RP). Rylander, R., Beijer, L., Lantz, R.C., Burrell, R., Sedivy, P. Int. Arch. Allergy Appl. Immunol. (1988)
- Treatment of human monocyte-derived macrophages with a TNF alpha synthesis inhibitor prior to HIV1 infection: consequences on cytokine production and viral replication. Le Naour, R., Raoul, H., Mabondzo, A., Henin, Y., Bousseau, A., Dormont, D. Res. Virol. (1994)