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Chemical Compound Review:

Br-Mmc 4-(bromomethyl)-7-methoxy- chromen-2-one

Synonyms: ACMC-1AGND, CCRIS 7996, AG-A-68462, AG-F-21487, ANW-42689, ...

Luckas, B., Abushufa, R. et al., Robinson, J.K. et al., Liu, H. et al., Peris Vicente, J. et al., et al.

Wang, Nano, Mulligan, Bush, Edom,

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High impact information on CCRIS 7996

After derivatization with 4-bromomethyl-7-methoxycoumarin, samples diluted in mobile phase (acetonitrile:water, 85:15 by vol) were injected onto a 250 x 4.6 mm C18 column, and the eluted fatty acids were detected fluorometrically [1].
Derivatization of 5-fluorouracil with 4-bromomethyl-7-methoxycoumarin for determination by liquid chromatography-mass spectrometry [2].
HPLC methods for the determination of the DSP toxins okadaic acid (OA) and dinophysistoxin-1 (DTX-1) are characterized by precolumn derivatization with 9-anthryldiazomethane (ADAM) and/or 4-bromomethyl-7-methoxycoumarin (Br-Mmc), followed by chromatographic separation of the DSP esters formed and fluorescence detection [3].
A sensitive assay for pilocarpine in biological fluids has been developed involving HPLC of a fluorescent derivative of 4-bromomethyl-7-methoxycoumarin [4].
A sensitive and selective analytical method based on high-performance liquid chromatography (HPLC) and fluorescent labeling with 4-bromomethyl-7-methoxycoumarin has been developed to quantify both thymine and thymine photodimers [5].

Analytical, diagnostic and therapeutic context of CCRIS 7996

Identification of lipid binders in old oil paintings by separation of 4-bromomethyl-7-methoxycoumarin derivatives of fatty acids by liquid chromatography with fluorescence detection [6].
A high-performance liquid chromatography (HPLC) method with isocratic elution has been established for the analysis of the 4-bromomethyl-7-methoxycoumarin (BrMMC) derivative of free VPA [7].

References

Fatty acids in erythrocytes measured by isocratic HPLC. Abushufa, R., Reed, P., Weinkove, C. Clin. Chem. (1994) [Pubmed]
Derivatization of 5-fluorouracil with 4-bromomethyl-7-methoxycoumarin for determination by liquid chromatography-mass spectrometry. Wang, K., Nano, M., Mulligan, T., Bush, E.D., Edom, R.W. J. Am. Soc. Mass Spectrom. (1998) [Pubmed]
Phycotoxins in seafood--toxicological and chromatographic aspects. Luckas, B. J. Chromatogr. (1992) [Pubmed]
Sensitive high-performance liquid chromatographic assay for pilocarpine in biological fluids using fluorescence derivatisation. Aromdee, C., Fawcett, J.P., Ledger, R. J. Chromatogr. B, Biomed. Appl. (1996) [Pubmed]
Derivatization of thymine and thymine photodimers with 4-bromomethyl-7-methoxycoumarin for fluorescence detection in high-performance liquid chromatography. Robinson, J.K., Scott, W.G., Rowlen, K.L., Birks, J.W. J. Chromatogr. B Biomed. Sci. Appl. (1999) [Pubmed]
Identification of lipid binders in old oil paintings by separation of 4-bromomethyl-7-methoxycoumarin derivatives of fatty acids by liquid chromatography with fluorescence detection. Peris Vicente, J., Gimeno Adelantado, J.V., Doménech Carbó, M.T., Mateo Castro, R., Bosch Reig, F. Journal of chromatography. A. (2005) [Pubmed]
Determination of free valproic acid: evaluation of the Centrifree system and comparison between high-performance liquid chromatography and enzyme immunoassay. Liu, H., Montoya, J.L., Forman, L.J., Eggers, C.M., Barham, C.F., Delgado, M. Therapeutic drug monitoring. (1992) [Pubmed]

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