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Chemical Compound Review:

Isoamylnitrile 3-methylbutanenitrile

Synonyms: ACMC-1B592, ANW-34242, NSC-148363, KB-70969, LS-86465, ...

Komeda, H. et al., Nagasawa, T. et al.

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Disease relevance of NSC 148363

The 1.4-kb downstream region from a nitrilase gene (nitA) of an actinomycete Rhodococcus rhodochrous J1, which is industrially in use, was found to be required for the isovaleronitrile-dependent induction of nitrilase synthesis in experiments using a Rhodococcus-Escherichia coli shuttle vector pK4 in a Rhodococcus strain [1].
A new type of nitrilase, arylacetonitrilase, has been purified from isovaleronitrile-induced cells of Alcaligenes faecalis JM3 in four steps [2].

High impact information on NSC 148363

By Northern blot analysis, the 1.4-kb transcripts for nitA were detected in R. rhodochrous J1 cells cultured in the presence of isovaleronitrile, but not those cultured in the absence of isovaleronitrile [1].

References

Transcriptional regulation of the Rhodococcus rhodochrous J1 nitA gene encoding a nitrilase. Komeda, H., Hori, Y., Kobayashi, M., Shimizu, S. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
A novel nitrilase, arylacetonitrilase, of Alcaligenes faecalis JM3. Purification and characterization. Nagasawa, T., Mauger, J., Yamada, H. Eur. J. Biochem. (1990) [Pubmed]

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