Disease relevance of Olivomycin

• Species-specific differences in the toxicity and mutagenicity of the anticancer drugs mithramycin, chromomycin A3, and olivomycin [1].

High impact information on Olivomycin

• These data suggest, therefore, that in addition to base composition, other factors are involved in the production of chromosome banding by chromomycin A3 and olivomycin [2].
• Characteristic reverse fluorescent banding patterns (R bands) on human, bovine, and mouse metaphase chromosomes are produced by treating chromosome preparations directly with olivomycin [3].
• Calf thymus DNA, with an intermediate G-C content of about 40 percent, showed a smaller fluorescence enhancement in the presence of olivomycin as was observed for the synthetic polynucleotide poly[d(G-C)] - poly [d(G-C)] [3].
• This enzyme immunoassay was specific to MTM and showed a very slight cross-reactivity with MTM analogues, chromomycin A3 (5.6%) and olivomycin (2.4%), but no cross-reactivity with drugs commonly used with MTM in combination chemotherapy for cancer treatment [4].
• The fluorochromes Hoechst 33258 and olivomycin are base pair specific DNA binding agents [5].

Biological context of Olivomycin

• Reverse banding on chromosomes produced by a guanosine-cytosine specific DNA binding antibiotic: olivomycin [3].
• Olivomycin induces tumor cell apoptosis and suppresses p53-induced transcription [6].
• The results of C-banding and olivomycin fluorescent banding suggest that at least three types of heterochromatin are contained in the porcine genome [7].
• Olivomycin (DNA-binding antibiotic) in nanomolar concentrations induces apoptosis of human tumor cells and inhibits p53-dependent transcription of the reporter gene (basal and induced by antitumor drugs) [6].

Associations of Olivomycin with other chemical compounds

• The closely related antibiotic chromomycin A3 showed the same results as were obtained with olivomycin either in the solution interaction with specific DNA's or with the netaphase chromosome preparations [3].
• Netropsin was also found to increase the differential fluorescent enhancement of complexes of olivomycin with DNAs of various base composition in solution [5].
• The variation of the fluorescence intensity of olivomycin-stained yeast cells as a function of the concentration of olivomycin, NaCl, and MgCl2 in the staining solution was studied [8].

Analytical, diagnostic and therapeutic context of Olivomycin

• With these reagents, a double-antibody enzyme immunoassay for CHM and for the CHM homologue olivomycin was developed which was highly sensitive and accurate enough to measure as little as 10 and 50 pg of each drug per assay tube, respectively [9].
• Cells of 82 species of Tetrapoda were stained with DNA base pair specific fluorochromes (Hoechst 33258 and olivomycin) and studied by means of flow cytometry [10].

References