Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

bromoheptane 1-bromoheptane

Synonyms: PubChem3775, NSC-7315, ACMC-1AYLH, B67570_ALDRICH, Heptyl bromide, ...

Moridani, M.Y., Gumpricht, E. et al.

Moridani,

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Disease relevance of NSC7315

It was found that dicoumarol, a diaphorase inhibitor, and 1-bromoheptane, a GSH depleting agent, increased 4-HA induced toxicity towards B16-F0 cells whereas dithiothreitol, a thiol containing agent, and ascorbic acid (AA), a reducing agent, largely prevented 4-HA toxicity [1].

High impact information on NSC7315

Depleting GSH by treating hepatocytes with 1-bromoheptane increased their sensitivity toward GCDC-induced cellular necrosis, but not apoptosis [2].

References

Biochemical basis of 4-hydroxyanisole induced cell toxicity towards B16-F0 melanoma cells. Moridani, M.Y. Cancer Lett. (2006) [Pubmed]
Glutathione status of isolated rat hepatocytes affects bile acid-induced cellular necrosis but not apoptosis. Gumpricht, E., Devereaux, M.W., Dahl, R.H., Sokol, R.J. Toxicol. Appl. Pharmacol. (2000) [Pubmed]

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