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Chemical Compound Review

AR-1L8705     [(2R,3S,4R,5S)-5- [(2S,3R,4S,5R)-3,4...

Synonyms: AC1L3X7S, Polyribophosphate, polyribose phosphate, Polyribosyl phosphate
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Disease relevance of Polyribosyl phosphate


High impact information on Polyribosyl phosphate


Chemical compound and disease context of Polyribosyl phosphate


Biological context of Polyribosyl phosphate


Anatomical context of Polyribosyl phosphate

  • In view of the persistent presence of type-specific capsular polysaccharide of H influenzae b (polyribophosphate [PRP]) in blood serum without any detectable anti-PRP antibody for 30 days following H influenzae b meningitis, monthly treatment with immune human serum globulin was undertaken until spontaneous production of anti-PRP antibody occurred [9].

Analytical, diagnostic and therapeutic context of Polyribosyl phosphate


  1. Circulating polyribophosphate in Hemophilus influenzae, type b meningitis. Correlation with clinical course and antibody response. O'Reilly, R.J., Anderson, P., Ingram, D.L., Peter, G., Smith, D.H. J. Clin. Invest. (1975) [Pubmed]
  2. Haemophilus influenzae type b infection in childhood: history of bacteremia and antigenemia. La Scolea, L.J., Rosales, S.V., Ogra, P.L. Infect. Immun. (1985) [Pubmed]
  3. The acquisition of anti-pneumococcal capsular polysaccharide Haemophilus influenzae type b and tetanus toxoid antibodies, with age, in the UK. Hazlewood, M., Nusrat, R., Kumararatne, D.S., Goodall, M., Raykundalia, C., Wang, D.G., Joyce, H.J., Milford-Ward, A., Forte, M., Pahor, A. Clin. Exp. Immunol. (1993) [Pubmed]
  4. Characterization of the immunoprotective antigen of ribosomal preparations from Haemophilus influenzae. Tewari, R.P., Lynn, M., Birnbaum, A.J., Solotorovsky, M. Infect. Immun. (1978) [Pubmed]
  5. Antibody of polyribophate of Haemophilus influenzae type b in infants and children: effect of immunization with polyribophosphate. Anderson, P., Smith, D.H., Ingram, D.L., Wilkins, J., Wehrle, P.F., Howie, V.M. J. Infect. Dis. (1977) [Pubmed]
  6. Altered antibody isotype in cystic fibrosis: impaired natural antibody response to polysaccharide antigens. Moss, R.B., Hsu, Y.P., Van Eede, P.H., Van Leeuwen, A.M., Lewiston, N.J., De Lange, G. Pediatr. Res. (1987) [Pubmed]
  7. Fetal-neonatal passive immunization against Hemophilus influenzae, type b. Amstey, M.S., Insel, R., Munoz, J., Pichichero, M. Am. J. Obstet. Gynecol. (1985) [Pubmed]
  8. Clinical studies of a new latex particle agglutination test for detection of Haemophilus influenzae type b polyribose phosphate antigen in serum, cerebrospinal fluid, and urine. Shaw, E.D., Darker, R.J., Feldman, W.E., Gray, B.M., Pifer, L.L., Scott, G.B. J. Clin. Microbiol. (1982) [Pubmed]
  9. Management of recurrent invasive Haemophilus influenzae infection. Fruchter, L., Insel, R. Am. J. Dis. Child. (1981) [Pubmed]
  10. Comparison of two antigen detection techniques in a primate model of Haemophilus influenzae type b infection. Scheifele, D.W., Daum, R.S., Syriopoulou, V.P., Siber, G.R., Smith, A.L. Infect. Immun. (1979) [Pubmed]
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