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Chemical Compound Review

LS-192339     tetracalcium hydroxy-dioxido-oxo...

Synonyms: AC1L3XI1, 13767-12-9, octacalcium phosphate, Phosphoric acid, calcium salt (3:4), 14096-86-7 (calcium-3/4H3PO4-5/8H2O), ...
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Disease relevance of octacalcium phosphate


Psychiatry related information on octacalcium phosphate


High impact information on octacalcium phosphate


Biological context of octacalcium phosphate


Anatomical context of octacalcium phosphate


Associations of octacalcium phosphate with other chemical compounds


Gene context of octacalcium phosphate

  • 15 mg of OCP combined with 1 microg of rhBMP-2 (OCP/BMP 1 microg), or 3 [27].
  • The precursor phase is thought to be octacalcium phosphate, which nucleates a HAP phase during SBF treatment [28].
  • In every solution, from which amorphous calcium phosphate, octacalcium phosphate, or apatite precipitated as a possible initial phase, osteonectin at concentrations less than 1 microM retarded the precipitation, subsequent transformation to apatite, and ripening crystal growth of apatite [29].
  • To study how crystal growth in dental enamel is controlled by the components of the extracellular matrix, we investigated the functional roles of amelogenins and fluoride ions in apatite formation occurring through an octacalcium phosphate (OCP)-precursor pathway [30].
  • The results show that the reaction undergoes the following process: transferring from octacalcium phosphate (OCP) to amorphous calcium phosphate (ACP) rapidly, and then from ACP to calcium-deficient hydroxyapatite (DAP) and HAP [31].

Analytical, diagnostic and therapeutic context of octacalcium phosphate


  1. Calcium and disease: molecular determinants of calcium crystal deposition diseases. Misra, R.P. Cell. Mol. Life Sci. (2000) [Pubmed]
  2. Periarthritis associated with basic calcium phosphate crystal deposition and low levels of serum alkaline phosphatase--report of three cases from one family. Caspi, D., Rosenbach, T.O., Yaron, M., McCarty, D.J., Graff, E. J. Rheumatol. (1988) [Pubmed]
  3. Octacalcium phosphate formation in vitro: implications for bone formation. Cheng, P.T. Calcif. Tissue Int. (1985) [Pubmed]
  4. High-resolution electron microscopy of octacalcium phosphate and its hydrolysis products. Nelson, D.G., McLean, J.D. Calcif. Tissue Int. (1984) [Pubmed]
  5. Phospholipids associated with human parotid gland sialoliths. Boskey, A.L., Burstein, L.S., Mandel, I.D. Arch. Oral Biol. (1983) [Pubmed]
  6. Conversion of octacalcium phosphate in calcium phosphate cements. De Maeyer, E.A., Verbeeck, R.M., Vercruysse, C.W. J. Biomed. Mater. Res. (2000) [Pubmed]
  7. The use of advanced diffraction methods in the study of the structure of a bioactive calcia: silica sol-gel glass. Newport, R.J., Skipper, L.J., Carta, D., Pickup, D.M., Sowrey, F.E., Smith, M.E., Saravanapavan, P., Hench, L.L. Journal of materials science. Materials in medicine (2006) [Pubmed]
  8. Serum and plasma inhibit neutrophil stimulation by hydroxyapatite crystals. Evidence that serum alpha 2-HS glycoprotein is a potent and specific crystal-bound inhibitor. Terkeltaub, R.A., Santoro, D.A., Mandel, G., Mandel, N. Arthritis Rheum. (1988) [Pubmed]
  9. Differential growth factor control of bone formation through osteoprogenitor differentiation. Chaudhary, L.R., Hofmeister, A.M., Hruska, K.A. Bone (2004) [Pubmed]
  10. Elongated growth of octacalcium phosphate crystals in recombinant amelogenin gels under controlled ionic flow. Iijima, M., Moriwaki, Y., Wen, H.B., Fincham, A.G., Moradian-Oldak, J. J. Dent. Res. (2002) [Pubmed]
  11. Implantation of octacalcium phosphate (OCP) in rat skull defects enhances bone repair. Kamakura, S., Sasano, Y., Homma, H., Suzuki, O., Kagayama, M., Motegi, K. J. Dent. Res. (1999) [Pubmed]
  12. Constant composition dissolution kinetics studies of human dentin. Paschalis, E.P., Tan, J., Nancollas, G.H. J. Dent. Res. (1996) [Pubmed]
  13. Physiochemical characterization of cardiovascular calcified deposits. I. Isolation, purification and instrumental analysis. Tomazic, B.B., Brown, W.E., Queral, L.A., Sadovnik, M. Atherosclerosis (1988) [Pubmed]
  14. Reversible structural changes of octacalcium phosphate and labile acid phosphate. Suzuki, O., Yagishita, H., Amano, T., Aoba, T. J. Dent. Res. (1995) [Pubmed]
  15. Bone marrow cell gene expression and tissue construct assembly using octacalcium phosphate microscaffolds. Shelton, R.M., Liu, Y., Cooper, P.R., Gbureck, U., German, M.J., Barralet, J.E. Biomaterials (2006) [Pubmed]
  16. Octacalcium phosphate combined with collagen orthotopically enhances bone regeneration. Kamakura, S., Sasaki, K., Honda, Y., Anada, T., Suzuki, O. J. Biomed. Mater. Res. Part B Appl. Biomater. (2006) [Pubmed]
  17. Intramembranaceous ossification analyses by a proton microprobe. Cichocki, T., Divoux, S., Gonsior, B., Höfert, M., Jarczyk, L., Raith, B., Rokita, E., Strzalkowski, A., Sych, M. Histochemistry (1990) [Pubmed]
  18. Osteoclastic resorption of biomimetic calcium phosphate coatings in vitro. Leeuwenburgh, S., Layrolle, P., Barrère, F., de Bruijn, J., Schoonman, J., van Blitterswijk, C.A., de Groot, K. J. Biomed. Mater. Res. (2001) [Pubmed]
  19. Elevated extracellular calcium stimulates secretion of bone morphogenetic protein 2 by a macrophage cell line. Honda, Y., Anada, T., Kamakura, S., Nakamura, M., Sugawara, S., Suzuki, O. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  20. Bone tissue engineering on amorphous carbonated apatite and crystalline octacalcium phosphate-coated titanium discs. Dekker, R.J., de Bruijn, J.D., Stigter, M., Barrere, F., Layrolle, P., van Blitterswijk, C.A. Biomaterials (2005) [Pubmed]
  21. Influence of calcium phosphate crystal assemblies on the proliferation and osteogenic gene expression of rat bone marrow stromal cells. Liu, Y., Cooper, P.R., Barralet, J.E., Shelton, R.M. Biomaterials (2007) [Pubmed]
  22. Morphology and microstructure of electrochemically deposited calcium phosphates in a modified simulated body fluid. Ban, S., Maruno, S. Biomaterials (1998) [Pubmed]
  23. The influence of fluoride on the seeded growth of apatite from stable supersaturated solutions at pH 7.4. Eanes, E.D. J. Dent. Res. (1980) [Pubmed]
  24. Calcium phosphate saturation levels in ultrafiltered serum. Eidelman, N., Chow, L.C., Brown, W.E. Calcif. Tissue Int. (1987) [Pubmed]
  25. Phosphate ions in bone: identification of a calcium-organic phosphate complex by 31P solid-state NMR spectroscopy at early stages of mineralization. Wu, Y., Ackerman, J.L., Strawich, E.S., Rey, C., Kim, H.M., Glimcher, M.J. Calcif. Tissue Int. (2003) [Pubmed]
  26. Osteoclastic responses to various calcium phosphates in cell cultures. Doi, Y., Iwanaga, H., Shibutani, T., Moriwaki, Y., Iwayama, Y. J. Biomed. Mater. Res. (1999) [Pubmed]
  27. New scaffold for recombinant human bone morphogenetic protein-2. Kamakura, S., Nakajo, S., Suzuki, O., Sasano, Y. Journal of biomedical materials research. Part A. (2004) [Pubmed]
  28. Porous calcium phosphate coating over phosphorylated chitosan film by a biomimetic method. Varma, H.K., Yokogawa, Y., Espinosa, F.F., Kawamoto, Y., Nishizawa, K., Nagata, F., Kameyama, T. Biomaterials (1999) [Pubmed]
  29. Osteonectin inhibiting de novo formation of apatite in the presence of collagen. Doi, Y., Okuda, R., Takezawa, Y., Shibata, S., Moriwaki, Y., Wakamatsu, N., Shimizu, N., Moriyama, K., Shimokawa, H. Calcif. Tissue Int. (1989) [Pubmed]
  30. Control of apatite crystal growth in a fluoride containing amelogenin-rich matrix. Iijima, M., Moradian-Oldak, J. Biomaterials (2005) [Pubmed]
  31. Kinetics of hydroxyapatite precipitation at pH 10 to 11. Liu, C., Huang, Y., Shen, W., Cui, J. Biomaterials (2001) [Pubmed]
  32. High-voltage electron microscopy of radiation damages in octacalcium phosphate. Aoba, T., Takahashi, J., Yagi, T., Doi, Y., Okazaki, M., Moriwaki, Y. J. Dent. Res. (1981) [Pubmed]
  33. Biomimetic synthesis of calcium-deficient hydroxyapatite in a natural hydrogel. Hutchens, S.A., Benson, R.S., Evans, B.R., O'Neill, H.M., Rawn, C.J. Biomaterials (2006) [Pubmed]
  34. Physicochemical properties of calcific deposits isolated from porcine bioprosthetic heart valves removed from patients following 2-13 years function. Tomazic, B.B., Brown, W.E., Schoen, F.J. J. Biomed. Mater. Res. (1994) [Pubmed]
  35. Biological performance of uncoated and octacalcium phosphate-coated Ti6Al4V. Habibovic, P., Li, J., van der Valk, C.M., Meijer, G., Layrolle, P., van Blitterswijk, C.A., de Groot, K. Biomaterials (2005) [Pubmed]
  36. Fluoride analysis of apatite crystals with a central planar OCP inclusion: concerning the role of F- ions on apatite/OCP/apatite structure formation. Iijima, M., Nelson, D.G., Pan, Y., Kreinbrink, A.T., Adachi, M., Goto, T., Moriwaki, Y. Calcif. Tissue Int. (1996) [Pubmed]
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