Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

CHEMBL161296 3-bis(2-chloroethylamino) phosphoryloxyprop...

Synonyms: AC1L3XXM, AR-1L2284, AC1Q6SY3, C16557, 53459-52-2, ...

Boal, J.H. et al., Preiss, R. et al.

Preiss, Schmidt, Baumann, Hanschmann, Hauss, Geissler, Pahlig, Ratzewiss,

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High impact information on Carboxyifosfamide

Because of the small amounts of the inactive metabolites keto- and carboxyifosfamide, the exclusive determination of acrolein only (free and protein-bound) seems to suffice for the calculation of total ifosfamide hydroxylation [1].
Concentrations of carboxyifosfamide (CBIF) formed in K562 cells were also greater than that in U937 cells [2].

References

Measurement of 4-hydroxylation of ifosfamide in human liver microsomes using the estimation of free and protein-bound acrolein and codetermination of keto- and carboxyifosfamide. Preiss, R., Schmidt, R., Baumann, F., Hanschmann, H., Hauss, J., Geissler, F., Pahlig, H., Ratzewiss, B. J. Cancer Res. Clin. Oncol. (2002) [Pubmed]
Direct detection of the intracellular formation of carboxyphosphamides using nuclear magnetic resonance spectroscopy. Boal, J.H., Ludeman, S.M., Ho, C.K., Engel, J., Niemeyer, U. Arzneimittel-Forschung. (1994) [Pubmed]

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