Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Chemical Compound Review:

Mannostatin (1R,2R,3R,4S,5R)-4-amino-5- methylsulfanyl...

Synonyms: Mannostatin A, CHEMBL9623, CHEBI:105642, LS-58048, BRN 4781487, ...

Tropea, J.E. et al., Ochi, Y. et al., Kawatkar, S.P. et al., Li, B. et al., Umezawa, K.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of BRN 4781487

Thus, in influenza virus infected Madin Darby canine kidney (MDCK) cells, mannostatin A blocked the normal formation of complex types of oligosaccharides on the viral glycoproteins and caused the accumulation of hybrid types of oligosaccharides [1].
A mannosidase inhibitor, mannostatin A, also inhibited in vitro invasion of mouse melanoma cells [2].

High impact information on BRN 4781487

The X-ray crystal structures of mannose trimming enzyme drosophila Golgi alpha-mannosidase II (dGMII) complexed with the inhibitors mannostatin A (1) and an N-benzyl analogue (2) have been determined [3].
Mannostatin A-treated B16/F10 cells also showed decreased metastatic activity in vivo in C57Bl/6 mice [4].
Mannostatin A did not inhibit the growth of either cell line at the concentration effective to inhibit invasion [4].

Biological context of BRN 4781487

Inhibition of Golgi mannosidase II with mannostatin A analogues: synthesis, biological evaluation, and structure-activity relationship studies [5].

References

Mannostatin A, a new glycoprotein-processing inhibitor. Tropea, J.E., Kaushal, G.P., Pastuszak, I., Mitchell, M., Aoyagi, T., Molyneux, R.J., Elbein, A.D. Biochemistry (1990) [Pubmed]
Inhibition of experimental metastasis by enzyme inhibitors from microorganisms and plants. Umezawa, K. Adv. Enzyme Regul. (1996) [Pubmed]
Structural basis of the inhibition of golgi alpha-mannosidase II by mannostatin A and the role of the thiomethyl moiety in ligand-protein interactions. Kawatkar, S.P., Kuntz, D.A., Woods, R.J., Rose, D.R., Boons, G.J. J. Am. Chem. Soc. (2006) [Pubmed]
Inhibition of tumor cell invasion in the Boyden chamber assay by a mannosidase inhibitor, mannostatin A. Ochi, Y., Atsumi, S., Aoyagi, T., Umezawa, K. Anticancer Res. (1993) [Pubmed]
Inhibition of Golgi mannosidase II with mannostatin A analogues: synthesis, biological evaluation, and structure-activity relationship studies. Li, B., Kawatkar, S.P., George, S., Strachan, H., Woods, R.J., Siriwardena, A., Moremen, K.W., Boons, G.J. Chembiochem (2004) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.