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Chemical Compound Review

Btzo-tdmap     benzotriazol-1-yloxy- tris(dimethylamino)ph...

Synonyms: Bop reagent, SureCN58561, AG-F-98921, KST-1A6214, AC1Q4XIL, ...
 
 
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High impact information on Btzo-tdmap

  • Cyclization in solution using BOP reagent gave the antagonist in 33% yield (13% overall) after HPLC purification [1].
  • Cyclic homooligomers of mannose-derived furanoid sugar amino acid 1 [H-Maa(Bn(2))-OH] were synthesized by using BOP reagent in the presence of DIPEA under dilute conditions that converted the sugar amino acid monomer directly into its cyclic homooligomers 3a and 4a [2].
  • The model peptide TRH was successfully synthesized using benzotriazol-1-yl-oxy-tris(dimethylamino)phosphonium hexafluorophosphate (BOP reagent) [3].
  • Furthermore, a comparison of the recently reported BOP reagent over the classical DIPC/HOBt method for the cyclisation reaction shows that in our case the reaction proceeded more rapidly by the BOP procedure although it gave a less pure crude product [4].
  • Total chemical synthesis of ubiquitin using BOP reagent: biochemical and immunochemical properties of the purified synthetic product [5].

References

  1. A convergent solution-phase synthesis of the macrocycle Ac-Phe-[Orn-Pro-D-Cha-Trp-Arg], a potent new antiinflammatory drug. Reid, R.C., Abbenante, G., Taylor, S.M., Fairlie, D.P. J. Org. Chem. (2003) [Pubmed]
  2. Cyclic homooligomers of furanoid sugar amino acids. Chakraborty, T.K., Srinivasu, P., Bikshapathy, E., Nagaraj, R., Vairamani, M., Kumar, S.K., Kunwar, A.C. J. Org. Chem. (2003) [Pubmed]
  3. BOP reagent for the coupling of pGlu and Boc-His(Tos) in solid phase peptide synthesis. Forest, M., Fournier, A. Int. J. Pept. Protein Res. (1990) [Pubmed]
  4. Synthesis of cyclic peptides on solid support. Application to analogs of hemagglutinin of influenza virus. Plaué, S. Int. J. Pept. Protein Res. (1990) [Pubmed]
  5. Total chemical synthesis of ubiquitin using BOP reagent: biochemical and immunochemical properties of the purified synthetic product. Briand, J.P., Van Dorsselaer, A., Raboy, B., Muller, S. Pept. Res. (1989) [Pubmed]
 
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