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Chemical Compound Review:

AIPP 2-amino-5-iodo-6-phenyl-1H- pyrimidin-4-one

Synonyms: CHEMBL37848, CCG-6770, CBMicro_018501, AG-G-87815, SureCN7769989, ...

Crowe, D. et al., Lotzová, E. et al., Lotzová, E. et al.

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Disease relevance of AIDS-186348

We have investigated the effect of pyrimidinone molecule 2-amino-5-iodo-6-phenyl-4 pyrimidinone (AIPP) on natural killer (NK) cell lytic potential and on the growth of ascitic mammary adenocarcinoma, ACA-755, in B6D2F1 mice [1].

High impact information on AIDS-186348

We have shown that pyrimidinone molecule, 2 amino-5-iodo-6-phenyl-4-pyrimidinone (AIPP) after regional administration, displayed both prophylactic and therapeutic effect on ascitic mammary adenocarcinoma, ACA-755 [2].

Associations of AIDS-186348 with other chemical compounds

The present study was carried out to determine the effects of treatment of mice with two 5-halopyrimidinones, 2-amino-5-bromo-6-phenyl-4(3H)-pyrimidinone (ABPP) and 2-amino-5-iodo-6-phenyl-4(3H)-pyrimidinone (AIPP), on the murine cytochrome P-450 system [3].

References

Induction of tumor immunity and natural killer cell cytotoxicity in mice by 5-halo-6-phenyl pyrimidinone. Lotzová, E., Savary, C.A., Pollack, S., Hanna, N. Cancer Res. (1986) [Pubmed]
Pyrimidinones: inducers of NK cell activity and antitumor immunity. Lotzová, E., Savary, C.A. Comp. Immunol. Microbiol. Infect. Dis. (1986) [Pubmed]
Effects of 5-halopyrimidinones with antiviral and antineoplastic activity on murine cytochrome P-450. Crowe, D., Nerland, D.E., Stringfellow, D.A., Sonnenfeld, G. Journal of biological response modifiers. (1984) [Pubmed]

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