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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Chemical Compound Review: 

AR-1J3322     (2S)-2-[2-[[(2S)-6-amino-2- [[(2S)-2,6...

Synonyms: AC1L2Q7Q, Lys-lys-gly-glu, beta-Endorphin MPF, Lysyl-lysyl-glycyl-glutamic acid, l-lysyl-l-lysylglycyl-l-glutamic acid
 
 
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High impact information on Lys-lys-gly-glu

  • The small cell lung carcinoma cell line U-1690 bound beta-endorphin via nonopioid binding sites also recognized by the C-terminal part of this opioid peptide Lys-Lys-Gly-Glu, but not by opiate alkaloids such as naloxone and morphine or other opioid peptides [1].
  • We have previously shown that a metabolically stable analogue of MPF, the C-terminal tetrapeptide of human beta-endorphin of structure Lys-Lys-Gly-Glu, reduces the turning behaviour of rats with unilateral lesions of their nigro-striatal pathways [2].
  • The C-terminal tetrapeptide of beta-endorphin (MPF) enhances lymphocyte proliferative responses [3].
 

Anatomical context of Lys-lys-gly-glu

  • Human MPF (Lys-Lys-Gly-Glu) stimulates the proliferative response of human lymphocytes to the T-cell mitogen concanavalin A by 121-751% in the concentration range 10(-11)-10(-4) M; the peak effect is at 10(-8) M, lower or higher concentrations eliciting reduced responses, i.e. the dose-response curve is bell-shaped [3].
 

Associations of Lys-lys-gly-glu with other chemical compounds

  • The output of dopamine from cultures of rat adrenal medullary strips was increased by 71-120% when Lys-Lys-Gly-Glu (MPF), the C-terminal tetrapeptide sequence of human beta-endorphin, was added to the culture medium at 100 micrograms/ml concentration [4].
 

Analytical, diagnostic and therapeutic context of Lys-lys-gly-glu

References

  1. Beta-endorphin stimulates proliferation of small cell lung carcinoma cells in vitro via nonopioid binding sites. Melzig, M.F., Nylander, I., Vlaskovska, M., Terenius, L. Exp. Cell Res. (1995) [Pubmed]
  2. Reversal of mitochondrial damage in a rat model of Parkinson's disease by a neurotrophic peptide (MPF analogue). Morley, J.S., Bazzaz, A.A., Ensor, D.M., Miles, J.B. Neuroreport (1994) [Pubmed]
  3. The C-terminal tetrapeptide of beta-endorphin (MPF) enhances lymphocyte proliferative responses. Owen, D.L., Morley, J.S., Ensor, D.M., Miles, J.B. Neuropeptides (1998) [Pubmed]
  4. Stimulation of dopamine output from adrenal medullary cells by beta-endorphin and its C-terminal tetrapeptide (MPF). Ensor, D.M., Morley, J.S., Redfern, R.M., Miles, J.B. Brain Res. (1989) [Pubmed]
  5. Neurotrophic effects of beta endorphin C-terminal tetrapeptide (MPF). Morley, J.S., Ensor, D.M. Neuropeptides (1986) [Pubmed]
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