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Chemical Compound Review

Terpentecin     2-[(2S)-2-[(1R)-2- [(1R,2R,3R,4aS,8aS)-3...

Synonyms: CHEBI:50301, LS-100983, LMPR0104040002, AC1L2S8E, MF 730N6, ...
 
 
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Disease relevance of MF 730N6

  • Terpentecin and ECT4B, new family of topoisomerase II targeting antitumor antibiotics produced by Streptomyces: producing organism, fermentation and large scale purification [1].
  • Terpentecin at a concentration of 0.78 microgram/ml decreased the number of viable cells of Escherichia coli NIHJ to less than one thousandth the starting number in an hour when added to an exponentially growing culture in a nutrient broth [2].
  • Terpentecin showed stronger antibacterial activities against Bacillus subtilis M45T (rec-) and E. coli BE1121 (rec A-) than against their corresponding wild type strains [2].
  • However, terpentecin showed no mutagenicity by the Ames test with Salmonella typhimurium strains TA100, TA98, TA92, TA1538, TA1537 and TA1535, and with E. coli WP2 (uvr A) [2].
  • Terpentecin at a lower concentration (0.07 micrograms/ml) inhibited growth in vitro of mouse leukemia L1210 cells by 50% [2].
 

High impact information on MF 730N6

  • Eubacterial diterpene cyclase genes essential for production of the isoprenoid antibiotic terpentecin [3].
  • In contrast to these conservative gene organizations, the biosynthetic genes of terpentecin, BE-40644, and furaquinocin A were located just upstream and/or downstream of the MV pathway gene cluster [4].
  • Streptomyces griseolosporeus MF730-N6, a terpenoid antibiotic-terpentecin (Tp) producer, has both the nonmevalonate and mevalonate pathways for the formation of IPP [5].
 

Chemical compound and disease context of MF 730N6

References

  1. Terpentecin and ECT4B, new family of topoisomerase II targeting antitumor antibiotics produced by Streptomyces: producing organism, fermentation and large scale purification. Kawada, S., Yamashita, Y., Ochiai, K., Ando, K., Iwasaki, T., Takiguchi, T., Nakano, H. J. Antibiot. (1995) [Pubmed]
  2. Terpentecin, an inhibitor of DNA synthesis. Tamamura, T., Tsuchiya, M., Isshiki, K., Sawa, T., Takeuchi, T., Hori, M., Sakata, N. J. Antibiot. (1988) [Pubmed]
  3. Eubacterial diterpene cyclase genes essential for production of the isoprenoid antibiotic terpentecin. Dairi, T., Hamano, Y., Kuzuyama, T., Itoh, N., Furihata, K., Seto, H. J. Bacteriol. (2001) [Pubmed]
  4. Studies on biosynthetic genes and enzymes of isoprenoids produced by actinomycetes. Dairi, T. J. Antibiot. (2005) [Pubmed]
  5. Growth-phase dependent expression of the mevalonate pathway in a terpenoid antibiotic-producing Streptomyces strain. Hamano, Y., Dairi, T., Yamamoto, M., Kuzuyama, T., Itoh, N., Seto, H. Biosci. Biotechnol. Biochem. (2002) [Pubmed]
  6. Cloning of a gene cluster encoding enzymes responsible for the mevalonate pathway from a terpenoid-antibiotic-producing Streptomyces strain. Hamano, Y., Dairi, T., Yamamoto, M., Kawasaki, T., Kaneda, K., Kuzuyama, T., Itoh, N., Seto, H. Biosci. Biotechnol. Biochem. (2001) [Pubmed]
 
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