Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

CHEMBL280395 8-methoxy-5-methylsulfanyl- 1,2,3,4...

Synonyms: SureCN8989387, SKF-89748, CHEBI:123600, KST-1B9275, AC1L2UGQ, ...

Matthews, W.D. et al., Morien, A. et al.

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High impact information on Skf 89748

The differential sensitivity to calcium entry blockade of the contractile responses of rat isolated aortas to the d- and l-isomers of SK&F 89748-A may reflect different ways of interaction of both enantiomers with the alpha-l adrenoceptor on rat aorta [1].
Calcium utilization in the vasoconstriction to enantiomers of SK&F 89748-A [1].
Amidephrine markedly suppressed food intake (ED50 = 0.49 mg/kg) and water intake (ED50 = 0.50 mg/kg), while SK&F 89748 marginally suppressed food intake (ED50 = 0.37 mg/kg) and was less potent in suppressing water intake (ED50 = 0.76 mg/kg) [2].

References

Calcium utilization in the vasoconstriction to enantiomers of SK&F 89748-A. Matthews, W.D., Macia, R.A., Beckeringh, J.J., DeMarinis, R.M., de Jonge, A., Thoolen, M.J., Wilffert, B., Timmermans, P.B., van Zwieten, P.A. J. Pharmacol. Exp. Ther. (1985) [Pubmed]
Effects on food and water intake of the alpha 1-adrenoceptor agonists amidephrine and SK&F-89748. Morien, A., McMahon, L., Wellman, P.J. Life Sci. (1993) [Pubmed]

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