Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Chemical Compound Review:

AC1L2UGW (2S)-N-[(1S)-1-aminocarbonyl- 2-phenyl...

Synonyms: 105129-00-8, Tyr-gly-leu-phe, alpha-Lactorphin

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Tyr-gly-leu-phe

In order to evaluate the antihypertensive mechanisms of alpha-lactorphin, the effects of the tetrapeptide on vascular function were investigated in (30-35 weeks old) spontaneously hypertensive rats (SHR) with established hypertension and age-matched normotensive Wistar-Kyoto (WKY) rats in vitro [1].

High impact information on Tyr-gly-leu-phe

alpha-lactorphin (Tyr-Gly-Leu-Phe) lowers blood pressure in conscious adult SHR [1].
Alpha-lactorphin dose-dependently lowered blood pressure (BP) without affecting heart rate in SHR and WKY [2].
Some of these inhibitory peptides, i.e. alpha-lactorphin (alpha-la f(50-53)), beta-lactorphin (beta-lg f(102-105)), beta-lactotensin (beta-lg f(146-149) and albutensin A (BSA f(208-216)), have other bioactivities [3].
Continuous hydrolysis of goat whey in an ultrafiltration reactor: generation of alpha-lactorphin [4].

References

Alpha-lactorphin and beta-lactorphin improve arterial function in spontaneously hypertensive rats. Sipola, M., Finckenberg, P., Vapaatalo, H., Pihlanto-Leppälä, A., Korhonen, H., Korpela, R., Nurminen, M.L. Life Sci. (2002) [Pubmed]
Alpha-lactorphin lowers blood pressure measured by radiotelemetry in normotensive and spontaneously hypertensive rats. Nurminen, M.L., Sipola, M., Kaarto, H., Pihlanto-Leppälä, A., Piilola, K., Korpela, R., Tossavainen, O., Korhonen, H., Vapaatalo, H. Life Sci. (2000) [Pubmed]
Lactokinins: whey protein-derived ACE inhibitory peptides. FitzGerald, R.J., Meisel, H. Die Nahrung. (1999) [Pubmed]
Continuous hydrolysis of goat whey in an ultrafiltration reactor: generation of alpha-lactorphin. Bordenave, S., Sannier, F., Ricart, G., Piot, J.M. Prep. Biochem. Biotechnol. (1999) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

Editor

Share