Disease relevance of Sulphamoxole

• Trimethoprim sulphamoxole in the treatment of chancroid. Comparison of two single dose treatment regimens with a five day regimen [1].
• Stevens-Johnson syndrome due to sulfuno (sulfamoxole) [2].

High impact information on Sulphamoxole

• The singlet oxygen quenching rates of the sulfa drugs were determined by laser flash photolysis and range from (2 +/- 1) x 10(4) M(-1) s(-1) for sulfamethoxazole to (3.0 +/- 0.7) x 10(8) M(-1) s(-1) for sulfamoxole [3].
• Experiments were undertaken with a new in vitro test system to establish whether the combination of sulfamoxole with trimethoprim will prevent the emergence of bacterial resistance [4].
• Chromatographic conditions were elaborated to evaluate a model mixture of four sulfonamides (sulfamethoxazole, sulfamoxole, sulfisoxazole and sulfamethoxydiazine) in plasma using a reversed phase HPLC C18 column and a mobile phase composed of methanol and phosphate buffer (60:40; v/v) at pH 5 [5].
• Oral bioavailability of sulphamethoxydiazine, sulphathiazole and sulphamoxole in dwarf goats [6].

References