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Chemical Compound Review:

CTK8G9315 2-butyldisulfanyl-1H-imidazole

Synonyms: AC1L30UP, 141400-57-9, III-2 Disulfide, 2-(Butyldithio)-1H-imidazole, n-Butyl 2-imidazolyl disulfide, ...

Kirkpatrick, D.L. et al., Oblong, J.E. et al.

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Disease relevance of III-2 Disulfide

A disulfide, n-butyl 2-imidazolyl disulfide (III-2), recently reported to be more toxic to EMT6 tumor cells under hypoxia has also been shown to be preferentially toxic to KHT/iv cells under hypoxia with an IC90 value 3-fold lower versus that measured in air [1].

High impact information on III-2 Disulfide

The effects of n-butyl 2-imidazolyl disulfide (III-2), 1-methylpropyl 2-imidazolyl disulfide (IV-2), and n-decyl 2-imidazolyl disulfide (VII-2) on purified human placental thioredoxin reductase activity were examined [2].

References

Effect of a hypoxic tumor cell cytotoxic disulfide on the membrane and DNA of tumor cells in culture. Kirkpatrick, D.L., King, K.M., Abu Sa'da, I., Kelln, R.A., Richardson, M.E., Siemann, D.W. Anticancer Drugs (1992) [Pubmed]
Reversible inhibition of human thioredoxin reductase activity by cytotoxic alkyl 2-imidazolyl disulfide analogues. Oblong, J.E., Chantler, E.L., Gallegos, A., Kirkpatrick, D.L., Chen, T., Marshall, N., Powis, G. Cancer Chemother. Pharmacol. (1994) [Pubmed]

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