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Chemical Compound Review

CTK8G9315     2-butyldisulfanyl-1H-imidazole

Synonyms: AC1L30UP, 141400-57-9, III-2 Disulfide, 2-(Butyldithio)-1H-imidazole, n-Butyl 2-imidazolyl disulfide, ...
 
 
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Disease relevance of III-2 Disulfide

  • A disulfide, n-butyl 2-imidazolyl disulfide (III-2), recently reported to be more toxic to EMT6 tumor cells under hypoxia has also been shown to be preferentially toxic to KHT/iv cells under hypoxia with an IC90 value 3-fold lower versus that measured in air [1].
 

High impact information on III-2 Disulfide

References

  1. Effect of a hypoxic tumor cell cytotoxic disulfide on the membrane and DNA of tumor cells in culture. Kirkpatrick, D.L., King, K.M., Abu Sa'da, I., Kelln, R.A., Richardson, M.E., Siemann, D.W. Anticancer Drugs (1992) [Pubmed]
  2. Reversible inhibition of human thioredoxin reductase activity by cytotoxic alkyl 2-imidazolyl disulfide analogues. Oblong, J.E., Chantler, E.L., Gallegos, A., Kirkpatrick, D.L., Chen, T., Marshall, N., Powis, G. Cancer Chemother. Pharmacol. (1994) [Pubmed]
 
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