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Chemical Compound Review:

Drnflrfamide (3S)-3-amino-3-[[(1S)-1- [[(1S)-2...

Synonyms: AC1L31R0, 149471-11-4, Neuropeptide DF2, DF(2) Neuropeptide, Asp-arg-asn-phe-leu-arg-phe-NH2

Badhwar, A. et al., Friedrich, R.W. et al., Friedrich, R.W. et al., Weiss, T. et al., Dunn, T.W. et al.

Dunn, Mercier,

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High impact information on Drnflrfamide

The crayfish neuropeptide DRNFLRFamide increases transmitter release from synaptic terminals onto muscle cells [1].
Localization of a FMRFamide-related peptide in efferent neurons and analysis of neuromuscular effects of DRNFLRFamide (DF2) in the crustacean Idotea emarginata [2].
The FMRFamide-related neuropeptide AspArgAsnPheLeuArgPhe-NH2 (DRNFLRFamide, DF2) induces a long-lasting enhancement of synaptic transmission at neuromuscular junctions on the crayfish deep abdominal extensor muscles [3].
Activators of PKA (Sp-cAMPS) and PKG (8-pCPT-cGMP) increase EPSP amplitude, mimicking the effects of DF2 [4].
DF2 (DRNFLRFamide), a FMRFamide-like peptide, has been shown to increase the amount of transmitter released at crayfish neuromuscular junctions [4].

Biological context of Drnflrfamide

The putative neurohormone DRNFLRFamide (DF2) increased EPSP amplitudes, but was more effective at 7-9 degrees C than at 15-17 degrees C. DF2 might play a hormonal role in counteracting low transmitter release at low temperature [5].

Associations of Drnflrfamide with other chemical compounds

Phosphodiesterase inhibitors, known to inhibit the breakdown of cAMP (IBMX) and/or cGMP (mdBAMQ), potentiate the effect of DF2 on synaptic transmission [4].

References

Synaptic modulation by a neuropeptide depends on temperature and extracellular calcium. Dunn, T.W., Mercier, A.J. J. Neurophysiol. (2003) [Pubmed]
Localization of a FMRFamide-related peptide in efferent neurons and analysis of neuromuscular effects of DRNFLRFamide (DF2) in the crustacean Idotea emarginata. Weiss, T., Kreissl, S., Rathmayer, W. Eur. J. Neurosci. (2003) [Pubmed]
Protein kinase C is required for long-lasting synaptic enhancement by the neuropeptide DRNFLRFamide in crayfish. Friedrich, R.W., Molnar, G.F., Schiebe, M., Mercier, A.J. J. Neurophysiol. (1998) [Pubmed]
A role for cyclic nucleotide monophosphates in synaptic modulation by a crayfish neuropeptide. Badhwar, A., Weston, A.D., Murray, J.B., Mercier, A.J. Peptides (2006) [Pubmed]
Temperature dependence of synaptic modulation by a FMRFamide-related neuropeptide in crayfish. Friedrich, R.W., Quigley, P.A., Srivastava, M., Skerrett, M., Mercier, A.J. Neurosci. Lett. (1994) [Pubmed]

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