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Chemical Compound Review:

H-Cys-OEt ethyl(2S)-2-amino-3-sulfanyl- propanoate

Synonyms: CHEMBL333513, CCRIS 2903, AG-F-15736, AC-19193, LS-59019, ...

Koivisto, T. et al., Rajendran, J.G. et al., Bergin, J.D. et al.

Rajendran, Lewis, Newell, Winn, Koivisto, Vanninen, Vanninen, Kuikka, Hernesniemi, Vapalahti,

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Disease relevance of Ethyl cysteine

METHODS: Cerebral perfusion was measured both before and 1 week after treatment by use of a (99m)Tc-labeled ethyl-cysteine dimer and single-photon emission computed tomographic (SPECT) studies in 46 of 81 consecutive patients included in a prospective randomized study of early treatment of ruptured aneurysms [1].
PURPOSE: The primary objective of this study was to correlate Tc-99m HMPAO and ethyl cysteine dimer perfusion brain SPECT imaging with angiography and transcranial Doppler (TCD) to identify vasospasm after subarachnoid hemorrhage [2].

High impact information on Ethyl cysteine

Ethyl D-cysteinate is a potent competitive inhibitor (Ki = 3.5 x 10(-7) M) of aminopeptidase M. D-cysteine and ethyl L-cysteinate inhibit more than two orders of magnitude less effectively [3].

References

Cerebral perfusion before and after endovascular or surgical treatment of acutely ruptured cerebral aneurysms: a 1-year prospective follow-up study. Koivisto, T., Vanninen, E., Vanninen, R., Kuikka, J., Hernesniemi, J., Vapalahti, M. Neurosurgery (2002) [Pubmed]
Brain SPECT used to evaluate vasospasm after subarachnoid hemorrhage: correlation with angiography and transcranial Doppler. Rajendran, J.G., Lewis, D.H., Newell, D.W., Winn, H.R. Clinical nuclear medicine. (2001) [Pubmed]
Inhibition of aminopeptidase M by alkyl D-cysteinates. Bergin, J.D., Clapp, C.H. J. Enzym. Inhib. (1989) [Pubmed]

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