Disease relevance of Catecholamic acid

• Both CBMIDA and EHBP were effective in excreting DU, reducing DU concentrations in organs, and preventing DU-induced toxicity, and CBMIDA was superior to EHBP, particularly in the prevention of renal dysfunction [1].

High impact information on Catecholamic acid

• The effects of pH on deleted uranium (DU) and DU removal by chelating agents, catechol-3,6-bis(methyleneiminodiacetic acid) (CBMIDA) and ethane-1-hydroxy-1,1-bisphoshonate (EHBP) in rats were examined [1].
• Mice were injected s.c. CBMIDA 1.5 or 2.5 g.kg-1 after Ni poisoning, the LD50 of NiCl2 were raised to 789 or 820 mg.kg-1, respectively [2].
• The excretions of 63Ni through urine and feces were not increased by CBMIDA at 24 h [2].
• METHODS: Mice and rats were injected s.c. or i.m. CBMIDA immediately after i.p. NiCl2 [2].

Gene context of Catecholamic acid

• In each pH group, five rats were injected intraperitoneally with 240 mg kg(-1) CBMIDA, and the other five with 10 mg kg(-1) EHBP; the remaining five were used as the corresponding group with no chelating agent [1].

Analytical, diagnostic and therapeutic context of Catecholamic acid

• Each mouse was injected i.p. CBMIDA after i.v. 63NiCl2 185 kBq, and radioactivities of various tissues were measured with liquid scintillation counter at 24 h [2].

References