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Chemical Compound Review:

PubChem9112 phenyldisulfanylbenzene

Synonyms: CHEMBL462861, NSC-2689, ACMC-1BM2Q, USAF E-1, ANW-75573, ...

Munday, R. et al., Choo, L.Y. et al., Modelli, A. et al., Shimizu, T. et al., Munday, R.

Modelli, Jones,

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Disease relevance of phenyldisulfanylbenzene

In ring-substituted diphenyl disulphide derivatives, electronic effects of substituents have been shown markedly to affect the rate of 'active oxygen' production in vitro and toxicity in vivo [1].

High impact information on phenyldisulfanylbenzene

The potency of 5-lipoxygenase inhibition by disulfiram was comparable to that of diphenyldisulfide (IC50 = 0.2-0.4 microM), in the same range or better than most typically used inhibitors [2].
Diphenyl disulphide has been shown to generate hydrogen peroxide in erythrocytes in vitro [3].

Analytical, diagnostic and therapeutic context of phenyldisulfanylbenzene

The absolute configuration of the P-helical enantiomer of diphenyl disulfide was determined by X-ray crystallography [4].
The temporary anion states of gas-phase diphenyl disulfide are characterized by means of electron transmission (ET) and dissociative electron attachment (DEA) spectroscopies [5].

References

Steric effects on the haemolytic activity of aromatic disulphides in rats. Munday, R., Manns, E., Fowke, E.A. Food Chem. Toxicol. (1990) [Pubmed]
Disulfiram is a potent inhibitor of rat 5-lipoxygenase activity. Choo, L.Y., Riendeau, D. Can. J. Physiol. Pharmacol. (1987) [Pubmed]
Toxicity of aromatic disulphides. II. Intraerythrocytic hydrogen peroxide formation and oxidative damage by aromatic disulphides. Munday, R. Journal of applied toxicology : JAT. (1985) [Pubmed]
Solid state optical activity of dichalcogenides: isolation by chiral crystallization and determination of absolute configuration. Shimizu, T., Isono, H., Yasui, M., Iwasaki, F., Kamigata, N. Org. Lett. (2001) [Pubmed]
Temporary anion states and dissociative electron attachment in diphenyl disulfide. Modelli, A., Jones, D. The journal of physical chemistry. A, Molecules, spectroscopy, kinetics, environment & general theory. (2006) [Pubmed]

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