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Chemical Compound Review

CHEMBL1615777     2-[(3- iodophenyl)methyl]guanidine

Synonyms: MOLI000966, AC1L367T, AC1Q50E3, D01729, (123)I-MIBG, ...
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Disease relevance of 3-Iodobenzylguanidine


Psychiatry related information on 3-Iodobenzylguanidine


High impact information on 3-Iodobenzylguanidine


Chemical compound and disease context of 3-Iodobenzylguanidine


Biological context of 3-Iodobenzylguanidine


Anatomical context of 3-Iodobenzylguanidine


Associations of 3-Iodobenzylguanidine with other chemical compounds

  • By multivariate Cox proportional hazard analysis, (123)I-MIBG (H/M or WoR), ANP and BNP were independent predictors for cardiac events [21].
  • All patients had (111)In Octreotide and 30 had (123)I mIBG scans followed by spiral CT with contrast enhancement [22].

Gene context of 3-Iodobenzylguanidine

  • CONCLUSION: Renal transplantation provides the improvement of uremic cardiac sympathetic neuropathy assessed by (123)I-MIBG imaging, which may be a more sensitive or at least an earlier marker than HRV [18].

Analytical, diagnostic and therapeutic context of 3-Iodobenzylguanidine


  1. Regional cardiac sympathetic denervation in patients with ventricular tachycardia in the absence of coronary artery disease. Mitrani, R.D., Klein, L.S., Miles, W.M., Hackett, F.K., Burt, R.W., Wellman, H.N., Zipes, D.P. J. Am. Coll. Cardiol. (1993) [Pubmed]
  2. 123I-MIBG myocardial scintigraphy in patients with "takotsubo" cardiomyopathy. Akashi, Y.J., Nakazawa, K., Sakakibara, M., Miyake, F., Musha, H., Sasaka, K. J. Nucl. Med. (2004) [Pubmed]
  3. Iodine-123-metaiodobenzylguanidine scintigraphy in patients with chemodectomas of the head and neck region. van Gils, A.P., van der Mey, A.G., Hoogma, R.P., Falke, T.H., Moolenaar, A.J., Pauwels, E.K., van Kroonenburgh, M.J. J. Nucl. Med. (1990) [Pubmed]
  4. Incremental prognostic implications of brain natriuretic peptide, cardiac sympathetic nerve innervation, and noncardiac disorders in patients with heart failure. Kyuma, M., Nakata, T., Hashimoto, A., Nagao, K., Sasao, H., Takahashi, T., Tsuchihashi, K., Shimamoto, K. J. Nucl. Med. (2004) [Pubmed]
  5. Evaluation of cardiac sympathetic innervation with iodine-123-metaiodobenzylguanidine imaging in silent myocardial ischemia. Matsuo, S., Takahashi, M., Nakamura, Y., Kinoshita, M. J. Nucl. Med. (1996) [Pubmed]
  6. 123I-Metaiodobenzylguanidine myocardial scintigraphy in panic disorder. Tanabe, Y., Harada, H., Sugihara, S., Ogawa, T., Inoue, Y. J. Nucl. Med. (2004) [Pubmed]
  7. Reduced myocardial (123)I-MIBG uptake in a patient with idiopathic rapid eye movement sleep behavior disorder. Kashihara, K., Imamura, T. Mov. Disord. (2007) [Pubmed]
  8. Value of 123I-MIBG radioactivity in the differential diagnosis of DLB from AD. Yoshita, M., Taki, J., Yokoyama, K., Noguchi-Shinohara, M., Matsumoto, Y., Nakajima, K., Yamada, M. Neurology (2006) [Pubmed]
  9. Effects of candesartan on cardiac sympathetic nerve activity in patients with congestive heart failure and preserved left ventricular ejection fraction. Kasama, S., Toyama, T., Kumakura, H., Takayama, Y., Ichikawa, S., Suzuki, T., Kurabayashi, M. J. Am. Coll. Cardiol. (2005) [Pubmed]
  10. Whole-Body PET/CT with 11C-Meta-Hydroxyephedrine in Tumors of the Sympathetic Nervous System: Feasibility Study and Comparison with 123I-MIBG SPECT/CT. Franzius, C., Hermann, K., Weckesser, M., Kopka, K., Juergens, K.U., Vormoor, J., Schober, O. J. Nucl. Med. (2006) [Pubmed]
  11. A scintigraphic comparison of iodine-123-metaiodobenzylguanidine and an iodine-labeled somatostatin analog (Tyr-3-octreotide) in metastatic carcinoid tumors. Bomanji, J., Mather, S., Moyes, J., Ellison, D., Grossman, A., Britton, K.E., Besser, G.M. J. Nucl. Med. (1992) [Pubmed]
  12. Radioisotope-guided surgery in patients with pheochromocytoma and recurrent medullary thyroid carcinoma: a comparison of preoperative and intraoperative tumor localization with histopathologic findings. Adams, S., Acker, P., Lorenz, M., Staib-Sebler, E., Hör, G. Cancer (2001) [Pubmed]
  13. Correlation between cardiac norepinephrine overflow during exercise and cardiac 123I-MIBG uptake in patients with chronic heart failure. Sato, M., Maehara, K., Yaoita, H., Otani, H., Hirosaka, A., Saito, T., Onuki, N., Komatsu, N., Ishihata, T., Maruyama, Y. J. Nucl. Med. (2003) [Pubmed]
  14. Iodine-123-metaiodobenzylguanidine myocardial imaging in patients with right ventricular pressure overload. Morimitsu, T., Miyahara, Y., Sinboku, H., Ikeda, S., Naito, T., Nishijima, K., Takao, M. J. Nucl. Med. (1996) [Pubmed]
  15. In vivo evidence of endothelial injury in chronic obstructive pulmonary disease by lung scintigraphic assessment of (123)I-metaiodobenzylguanidine. Arao, T., Takabatake, N., Sata, M., Abe, S., Shibata, Y., Honma, T., Takahashi, K., Okada, A., Takeishi, Y., Kubota, I. J. Nucl. Med. (2003) [Pubmed]
  16. Technetium-99m labeled 1-(4-fluorobenzyl)-4-(2-mercapto-2-methyl-4-azapentyl)-4-(2-mercapto-2-methylpropylamino)-piperidine and iodine-123 metaiodobenzylguanidine for studying cardiac adrenergic function: a comparison of the uptake characteristics in vascular smooth muscle cells and neonatal cardiac myocytes, and an investigation in rats. Samnick, S., Scheuer, C., Münks, S., El-Gibaly, A.M., Menger, M.D., Kirsch, C.M. Nucl. Med. Biol. (2004) [Pubmed]
  17. Is abnormal iodine-123-MIBG kinetics associated with left ventricular dysfunction in patients with diabetes mellitus? Sugiyama, T., Kurata, C., Tawarahara, K., Nakano, T. Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology. (2000) [Pubmed]
  18. Improvement of cardiac sympathetic innervation by renal transplantation. Kurata, C., Uehara, A., Ishikawa, A. J. Nucl. Med. (2004) [Pubmed]
  19. Myocardial iodine-123-metaiodobenzylguanidine images and autonomic nerve activity in normal subjects. Morozumi, T., Kusuoka, H., Fukuchi, K., Tani, A., Uehara, T., Matsuda, S., Tsujimura, E., Ito, Y., Hori, M., Kamada, T., Nishimura, T. J. Nucl. Med. (1997) [Pubmed]
  20. Iodine-123-MIBG SPECT versus planar imaging in children with neural crest tumors. Gelfand, M.J., Elgazzar, A.H., Kriss, V.M., Masters, P.R., Golsch, G.J. J. Nucl. Med. (1994) [Pubmed]
  21. Clinical implications of cardiac (123)I-meta-iodobenzylguanidine scintigraphy and cardiac natriuretic peptides in patients with heart disease. Ebina, T., Takahashi, N., Mitani, I., Sumita, S., Ishigami, T., Ashino, K., Minamisawa, K., Kuji, N., Ochiai, H., Ishikawa, Y., Oka, T., Inoue, T., Matsubara, S., Umemura, S. Nuclear medicine communications. (2002) [Pubmed]
  22. Comparison of functional imaging and standard CT in evaluation of disease extent in patients with tumours showing neuroendocrine features. Cwikła, J.B., Buscombe, J.R., Mielcarek, W.A., Caplin, M.E., Watkinson, A.J., Hilson, A.J. Nuclear medicine review. Central & Eastern Europe : journal of Bulgarian, Czech, Macedonian, Polish, Romanian, Russian, Slovak, Yugoslav societies of nuclear medicine and Ukrainian Society of Radiology. (2001) [Pubmed]
  23. Iodine-123-metaiodobenzylguanidine SPECT of regional cardiac adrenergic denervation in Brugada syndrome. Agostini, D., Scanu, P., Loiselet, P., Babatasi, G., Darlas, Y., Grollier, G., Potier, J.C., Bouvard, G. J. Nucl. Med. (1998) [Pubmed]
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