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Chemical Compound Review:

CCRIS 406 N-methyl-N-propyl-nitrous amide

Synonyms: CHEMBL165385, LS-125715, AKOS006283547, BRN 1745070, AC1L21Y6, ...

Thomson, J.A. et al., Dickhaus, S. et al., Farrelly, J.G. et al., Sheweita, S.A. et al.

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Disease relevance of N-methyl-N-propyl-nitrous amide

Di-n-propylnitrosamine (DPN) and methyl-n-propylnitrosamine (MPN) induced mainly respiratory tract neoplasms in female NMRI mice after subcutaneous administration [1].
Carcinogenic N-nitrosamines were tested for their ability to induce lambda in a lysogenic strain of Escherichia coli K-12 (58-161 F+ Dimethylnitrosamine, di-n-propylnitrosamine, methyl-n-propylnitrosamine, and N-nitrosopiperidine were shown to be inducers of prophage [2].

High impact information on N-methyl-N-propyl-nitrous amide

All the nitrosamines with the exception of nitrosomethylpropylamine exhibited simple Michaelis-Menten kinetics [3].
Methylpropylnitrosamine decreased the activity of DMN-dI by 44% and the P-450 content by 50% [4].

References

The carcinogenic effect of beta-oxidized dipropylnitrosamine in mice. I. Dipropylnitrosamine and methyl-propylnitrosamine. Dickhaus, S., Reznik, G., Green, U., Ketkar, M. Zeitschrift für Krebsforschung und klinische Onkologie. Cancer research and clinical oncology. (1977) [Pubmed]
Prophage induction of Escherichia coli (lambda) by N-nitrosamines. Thomson, J.A., Woods, D.R. Applied microbiology. (1975) [Pubmed]
The metabolism of a series of methylalkylnitrosamines. Farrelly, J.G., Stewart, M.L. Carcinogenesis (1982) [Pubmed]
N-nitroso compounds induce changes in carcinogen-metabolizing enzymes. Sheweita, S.A., Mostafa, M.H. Cancer Lett. (1996) [Pubmed]

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