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Chemical Compound Review:

CPD-9155 1-chloro-4-nitroso-benzene

Synonyms: AG-H-81318, NSC-202930, CTK5H2275, NSC202930, AKOS006274059, ...

Doerge, D.R. et al., Golly, I. et al.

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Disease relevance of NSC 202930

The reaction of bovine (Bos taurus) and porcine (Sus scrufa) cardiac alpha-ketoglutarate dehydrogenase complex (alpha-KGD) with 4-chloronitrosobenzene (I) was shown to produce a hydroxamic acid (IV) and a product due to a Bamberger rearrangement as previously shown for Escherichia coli alpha-KGD [1].

High impact information on NSC 202930

4-Chloroaniline undergoes N-oxidation in ram seminal-vesicle microsomal preparations supplemented with arachidonic acid to yield N-(4-chlorophenyl)-hydroxylamine and 1-chloro-4-nitrosobenzene [2].
The action of alpha-ketoglutarate dehydrogenase on 4-chloronitrosobenzene: evidence for species-dependent differences in active site properties [1].

References

The action of alpha-ketoglutarate dehydrogenase on 4-chloronitrosobenzene: evidence for species-dependent differences in active site properties. Doerge, D.R., Corbett, M.D. Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol. (1985) [Pubmed]
N-Oxidation of 4-chloroaniline by prostaglandin synthase. Redox cycling of radical intermediate(s). Golly, I., Hlavica, P. Biochem. J. (1985) [Pubmed]

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