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Chemical Compound Review:

SureCN543480 4-hydroxy-N-[(5-nitro-2...

Synonyms: CBMicro_014685, AG-H-95592, ACMC-20p1ec, SPBio_002550, CTK8F1044, ...

Ayad, M.M. et al., Rando, D.G. et al., Barbosa, J. et al., Hayder, N. et al., Scarpignato, C. et al., et al.

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Disease relevance of Nifuroxazide

Nifuroxazide was positive in the Ames test in two Salmonella strains (TA100, and TA100 Fr1) [1].
The effect of extracts from leaves of Myrtus communis on the SOS reponse induced by Aflatoxin B1 (AFB1) and Nifuroxazide was investigated in a bacterial assay system, i.e. the SOS chromotest with Escherichia coli PQ37 [2].
Occupational contact allergy to nifuroxazide simulating prurigo nodularis [3].
Nitroaromatic compounds such as nifuroxazide are used in many human enteropathogenic bacteria infections without causing an increase in the plasmidial antibiotic resistance of the aerobic Gram-negative intestinal Enterobacteriaceae [4].
Granulocytopenia due to nifuroxazide followed by a G-CSF-induced leukemoid reaction [5].

High impact information on Nifuroxazide

Three spectrophotometric methods including Vierordt's method, derivative, ratio spectra derivative, and thin layer chromatography (TLC)-UV densitometric method were developed for simultaneous determination of drotaverine HCl (DRT) and nifuroxazide (NIF) in presence of its impurity, 4-hydroxybenzohydrazide (4-HBH) [6].
The present multi-compound method was capable of measuring very low concentrations of nitrofurantoin (NFT), nitrofurazone (NFZ), furazolidone (FZD) and furaltadone (FTD) in animal feed using nifuroxazide (NXZ) as internal standard [7].
In vivo activity of nifurzide and nifuroxazide in intestinal bacteria in man and gnotobiotic mice [8].

Analytical, diagnostic and therapeutic context of Nifuroxazide

Determination of nifuroxazide in biological fluids by automated high-performance liquid chromatography with large-volume injection [9].
A comparative study on various spectrometries with thin layer chromatography for simultaneous analysis of drotaverine and nifuroxazide in capsules [6].
Double-blind study of traveller's diarrhoea using Nifuroxazide [10].
Others (e.g. nifuroxazide or rifaximin), which have been found effective in various homeland forms of infective diarrhea deserve to be evaluated in specifically designed clinical trials [11].

References

Study of the mutagenic activity of 6 hepatotoxic pharmaceutical drugs in the Salmonella typhimurium microsome test, and the HGPRT and Na+/K+ ATPase system in cultured mammalian cells. Dayan, J., Deguingand, S., Truzman, C. Mutat. Res. (1985) [Pubmed]
Anti-genotoxic and free-radical scavenging activities of extracts from (Tunisian) Myrtus communis. Hayder, N., Abdelwahed, A., Kilani, S., Ammar, R.B., Mahmoud, A., Ghedira, K., Chekir-Ghedira, L. Mutat. Res. (2004) [Pubmed]
Occupational contact allergy to nifuroxazide simulating prurigo nodularis. Kieć-Swierczyńska, M., Krecisz, B. Contact Derm. (1998) [Pubmed]
Potential tuberculostatic agents. Topliss application on benzoic acid [(5-nitro-thiophen-2-yl)-methylene]-hydrazide series. Rando, D.G., Sato, D.N., Siqueira, L., Malvezzi, A., Leite, C.Q., do Amaral, A.T., Ferreira, E.I., Tavares, L.C. Bioorg. Med. Chem. (2002) [Pubmed]
Granulocytopenia due to nifuroxazide followed by a G-CSF-induced leukemoid reaction. Karaaslan, Y., Haznedaroğlu, S., Ozilkan, E., Kaftan, O. The Annals of pharmacotherapy. (1999) [Pubmed]
A comparative study on various spectrometries with thin layer chromatography for simultaneous analysis of drotaverine and nifuroxazide in capsules. Ayad, M.M., Youssef, N.F., Abdellatif, H.E., Soliman, S.M. Chem. Pharm. Bull. (2006) [Pubmed]
Determination of nitrofurans in animal feeds by liquid chromatography-UV photodiode array detection and liquid chromatography-ionspray tandem mass spectrometry. Barbosa, J., Moura, S., Barbosa, R., Ramos, F., da Silveira, M.I. Anal. Chim. Acta (2007) [Pubmed]
In vivo activity of nifurzide and nifuroxazide in intestinal bacteria in man and gnotobiotic mice. Leonard, F., Andremont, A., Tancrede, C. J. Appl. Bacteriol. (1985) [Pubmed]
Determination of nifuroxazide in biological fluids by automated high-performance liquid chromatography with large-volume injection. Guinebault, P.R., Broquaire, M., Braithwaite, R.A. J. Chromatogr. (1981) [Pubmed]
Double-blind study of traveller's diarrhoea using Nifuroxazide. Bourée, P., Kouchner, G., Ponti, M. Trans. R. Soc. Trop. Med. Hyg. (1987) [Pubmed]
Prevention and treatment of traveler's diarrhea: a clinical pharmacological approach. Scarpignato, C., Rampal, P. Chemotherapy. (1995) [Pubmed]

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