High impact information on acetonitrile

• Identification of the interstellar cyanomethyl radical (CH2CN) in the molecular clouds TMC-1 and Sagittarius B2 [1].
• Several parameters such as concentration of acetonitrile (ACN), pH, as well as applied voltage were studied to optimize the EKC separation [2].
• It is observed that in the limited concentration ranges used in the MEKC systems the effect of organic modifier concentration on the retention can be described by the equation logk1=logk1w-SC for most binary aqueous-organic buffer, but deviations from this retention equation are observed at ACN and particularly THF as organic modifiers [3].
• The proposal used ACN as an interaction organic modifier between D,L-dansyl amino acids and their binding site in human serum albumin at site II [4].
• The coupled-column separation has been achieved by use of a C18 column with methanol as the mobile phase followed by a DiamondBond C18 column with acetonitrile (ACN) mobile phase [5].

Biological context of acetonitrile

• However, after suspension culture with GM-CSF, IL-3, and SLF, they were placed into rapid cell cycle and were responsive to inhibition by ACN-treated chemokines [6].

Anatomical context of acetonitrile

• Combinations of any two of these ACN-treated chemokines synergized to suppress colony formation of CFU-GM, BFU-E, and CFU-GEMM at chemokine concentrations below that at which combinations of non-ACN treated chemokines are active [6].

Associations of acetonitrile with other chemical compounds

• PEG-b-PCL micelles with encapsulated fenofibrate were prepared through the removal of a negative ACN-water azeotrope under reduced pressure [7].
• After endcapping with TMSI in acetonitrile (ACN), all columns provided better performance for hydrogen-bonding compounds and basic compounds than C(18) phases endcapped with HMDS [8].
• Water, methanol (MeOH), acetonitrile (ACN), and binary MeOH-water and ACN-water solutions of different spin probes (nitroxides), selected to mimic the behavior of different pollutants, were adsorbed onto stationary phases usually used in reversed-phase high-performance liquid chromatography (RP-HPLC) [9].
• Both steady-state and time-resolved spectroscopic measurements in the polar acetonitrile (ACN) and ethanol (EtOH) solvents show that the fluorescence quenching phenomenon of 9CNA in presence of 2PI is primarily due to the involvement of dynamic process which in high probability should be PET [10].
• Several response functions were evaluated and indicated 10 mmol L(-1) TBS (pH 10.1), 15% ACN, and 20 mmol L(-1) Brij 35 as best values [11].

Gene context of acetonitrile

• SP-B presented a very stable conformation in all the assayed ACN/water mixtures and in TFE/water mixtures containing until 70% TFE, showing around 40% alpha-helix [12].
• The binding constants were determined as Kd = 11, 12.5 and 16.2 microM for 5, 10 and 30% ACN, respectively [13].
• In the unsaturated soil, however, ACN at 1.0% inhibited RDX loss by as much as 25% [14].
• A set of well resolved and more uniformly spaced peaks was obtained with an electrolyte consisting of 7.5 mmol L(-1) TBS (pH 10.1), 10 mmol L(-1) Brij, and 15% ACN [11].
• Bovine serum albumin (BSA) was used to optimize acetonitrile (ACN) elution gradient for tryptic peptides, and Cytochrome C was used to retest the gradient and the sensitivity of LC-MS/MS [15].

Analytical, diagnostic and therapeutic context of acetonitrile

• In HPLC experiments, variation of acetonitrile (ACN) content in the mobile phase showed that peptides are mainly separated by RP mechanism [16].
• Despite showing coelution of proteins, solid-phase extraction (SPE) methods exhibited superior plasma peptide recovery than ultrafiltration, acetonitrile (ACN) precipitation, or size-exclusion chromatography methods under conditions employed in the study [17].

References