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Chemical Compound Review:

Guancidina 1-cyano-2-(2-methylbutan-2- yl)guanidine

Synonyms: Guancidine, Guancydine, Guancidinum, CHEMBL1697839, CL-2422, ...

Petersen, H.J. et al., Villarreal, H. et al., Hărăgus, S.T. et al.

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Disease relevance of Guancidine

Effect of guancydine on systemic and renal hemodynamics in arterial hypertension [1].
Guancydine was given for 7 to 18 days at an average dose of 21 mg/kg of body weight [1].

High impact information on Guancidine

In comparison with guancydine, which is the de-3-pyridyl analogue of 20, a 150-fold increase of potency in spontaneously hypertensive rats was obtained with 20 and its tert-butyl analogue 19 [2].
The hypotensive effect of Guancydine is associated with a decrease of platelet adhesiveness and an activation of fibrinolysis [3].

References

Effect of guancydine on systemic and renal hemodynamics in arterial hypertension. Villarreal, H., Arcila, H., Ramírez, M.A., Sierra, P. Mayo Clin. Proc. (1977) [Pubmed]
Synthesis and hypotensive activity of N-alkyl-N"-cyano-N'-pyridylguanidines. Petersen, H.J., Nielsen, C.K., Arrigoni-Martelli, E. J. Med. Chem. (1978) [Pubmed]
Guancydine, a new hypotensive agent with complex action. Hărăgus, S.T., Uza, G., Duncea, C. Cor et vasa. (1977) [Pubmed]

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