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Chemical Compound Review

Decabrom     1,2,3,4,5-pentabromo-6- (2,3,4,5,6...

Synonyms: DecaBDE, DPBPO, Dbdpo, Deca-BDE, FR-PE, ...
 
 
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High impact information on Decabrom

  • The most remarkable findings in this study were the large contribution of the highest brominated BDEs (hepta- to deca-BDE), and principally BDE 209, to the total BDE concentration found in Spanish foods, except fish and shellfish, and the presence of BDE 184, 191, 196, and 197 in many of the samples [1].
  • In vivo and in vitro debromination of decabromodiphenyl ether (BDE 209) by juvenile rainbow trout and common carp [2].
  • DP atmospheric concentrations were comparable to those of BDE-209 at the eastern Great Lakes sites [3].
  • In contrast, carp liver microsomes biotransformed up to 65% of the BDE 209 mass, primarily down to hexaBDE congeners [2].
  • Based on the total body burden of the hepta- through decaBDE congeners, uptake of BDE 209 was estimated at 3.2% [2].
 

Biological context of Decabrom

  • Because this compound is very hydrophobic (log K(ow) approximately 10), it has been suggested that BDE 209 has very low bioavailability, although debromination to more bioavailable metabolites has also been suggested to occur in fish tissues [4].
  • Thus, higher-brominated PBDEs, including BDE-209, are bioavailable from soils and accumulate in earthworms, presenting an exposure pathway into the terrestrial food web [5].
  • For BDE-209 the levels observed in year 2000 were even lower than in referents with no occupational exposure [6].
 

Anatomical context of Decabrom

  • In animals with the highest BDE 209 levels, this congener was detected in muscle, liver, as well as in adipose tissue [7].
 

Associations of Decabrom with other chemical compounds

  • During the development of a method to determine polybrominated diphenyl ethers (PBDEs) using GC/MS-MS equipped with a programmed temperature vaporizer (PTV) injector, a dramatic decrease in sensitivity to decabromodiphenyl ether (BDE-209) occurred and lack of sensitivity and repeatability was observed [8].
 

Gene context of Decabrom

  • Nine BDE congeners, including BDE-209, were identified and quantified [9].
  • During the initial reaction period of BDE 209 (<5 days), hexa- to heptabromo BDEs were the most abundant products, but tetra- to pentabromo congeners were dominant after 2 weeks [10].
  • The apparent similarities in chemical structure between the DBDPO, polychlorinated and polybrominated biphenyl (PCB, PBB) molecules have led to the presumption that these substances also share similar toxicological and environmental properties [11].
 

Analytical, diagnostic and therapeutic context of Decabrom

  • Finally, a double system based on the programmed temperature vaporizer injector/MS detector (for tri- to hepta-BDEs) and on-column injector/electron-capture detector (for BDE-209) was evaluated using two candidate certified materials (fish muscle tissue and river sediment) [8].
  • The range of "2,3,7,8-TCDD equivalents" levels (micrograms/g or ppm) derived from values obtained from the AHH and EROD bioassays for each of the pyrolyzed flame retardant samples was: 174-194, 480-1400, 2140-4680, 6740-8780 and 3920-5260 ppm for FR 300 BA, FireMaster BP-6, Bromkal 70 DE, Bromkal 70-5 DE and Bromkal G1, respectively [12].

References

  1. Survey of polybrominated diphenyl ether levels in Spanish commercial foodstuffs. Gómara, B., Herrero, L., González, M.J. Environ. Sci. Technol. (2006) [Pubmed]
  2. In vivo and in vitro debromination of decabromodiphenyl ether (BDE 209) by juvenile rainbow trout and common carp. Stapleton, H.M., Brazil, B., Holbrook, R.D., Mitchelmore, C.L., Benedict, R., Konstantinov, A., Potter, D. Environ. Sci. Technol. (2006) [Pubmed]
  3. Dechlorane plus, a chlorinated flame retardant, in the gReat Lakes. Hoh, E., Zhu, L., Hites, R.A. Environ. Sci. Technol. (2006) [Pubmed]
  4. Debromination of the flame retardant decabromodiphenyl ether by juvenile carp (Cyprinus carpio) following dietary exposure. Stapleton, H.M., Alaee, M., Letcher, R.J., Baker, J.E. Environ. Sci. Technol. (2004) [Pubmed]
  5. Effect of sewage-sludge application on concentrations of higher-brominated diphenyl ethers in soils and earthworms. Sellström, U., de Wit, C.A., Lundgren, N., Tysklind, M. Environ. Sci. Technol. (2005) [Pubmed]
  6. Polybrominated diphenyl ether exposure to electronics recycling workers - a follow up study. Thuresson, K., Bergman, K., Rothenbacher, K., Herrmann, T., Sjölin, S., Hagmar, L., Päpke, O., Jakobsson, K. Chemosphere (2006) [Pubmed]
  7. Remarkable findings concerning PBDEs in the terrestrial top-predator red fox (Vulpes vulpes). Voorspoels, S., Covaci, A., Lepom, P., Escutenaire, S., Schepens, P. Environ. Sci. Technol. (2006) [Pubmed]
  8. Improvements in the analysis of decabromodiphenyl ether using on-column injection and electron-capture detection. Binelli, A., Roscioli, C., Guzzella, L. Journal of chromatography. A (2006) [Pubmed]
  9. Large-volume programmed-temperature vaporiser injection for fast gas chromatography with electron capture and mass spectrometric detection of polybrominated diphenyl ethers. Tollbäck, P., Björklund, J., Ostman, C. Journal of chromatography. A. (2003) [Pubmed]
  10. Reductive debromination of polybrominated diphenyl ethers by zerovalent iron. Keum, Y.S., Li, Q.X. Environ. Sci. Technol. (2005) [Pubmed]
  11. A comparison of the properties of the major commercial PBDPO/PBDE product to those of major PBB and PCB products. Hardy, M.L. Chemosphere (2002) [Pubmed]
  12. Applications of the in vitro aryl hydrocarbon hydroxylase induction assay for determining "2,3,7,8-tetrachlorodibenzo-p-dioxin equivalents": pyrolyzed brominated flame retardants. Zacharewski, T., Harris, M., Safe, S., Thoma, H., Hutzinger, O. Toxicology (1988) [Pubmed]
 
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