Disease relevance of NSC 29027

• The nucleotide sequence of a 10,528-bp region comprising the chlorocatechol pathway gene cluster tetRtetCDEF of the 1,2,3,4-tetrachlorobenzene via the tetrachlorocatechol-mineralizing bacterium Pseudomonas chlororaphis RW71 (T. Potrawfke, K. N. Timmis, and R.-M. Wittich, Appl. Environ. Microbiol. 64:3798-3806, 1998) was analyzed [1].

High impact information on NSC 29027

• The analogous SERR difference spectroscopy experiment is also carried out for the enzyme-inhibitor (EI) complex of CCD with tetrachlorocatechol (TCC) [2].
• In contrast, 4c, which is prepared from a 1:2 molar mixture of B(OH)(3) and tetrachlorocatechol, is effective as a Lewis acid-assisted Brønsted acid (LBA) catalyst for Ritter reaction [3].
• The catechol 1,2-dioxygenase from strain CH34 is unique in its property to transform tetrachlorocatechol; however, excess substrate led to a marked reversible inhibition [4].
• Product identification suggested that the reaction may include two parallel reactions to form either dimers or 2,3,5,6-tetrachloro-1,4-hydroquinone and tetrachlorocatechol via simultaneous dehydrochlorination and hydroxylation [5].
• The formation of tetrachlorocatechol during biotransformation was monitored, and its inhibitory effect on growth of strain PH-05 was analyzed at a range of concentrations [6].

Biological context of NSC 29027

• The kinetics of decomposition of tetrachlorobenzo-1,2-quinone in aqueous solutions were studied in detail and showed the formation of tetrachlorocatechol, 2,5-dichloro-3,6-dihydroxybenzo-1,4-quinone, 1,2,3-trihydroxy-4,5,6-trichlorobenzene, 1,2,4-trihydroxy-3,5,6-trichlorobenzene, dichloromaleic acid, and a trichlorocyclopentendione [7].

Analytical, diagnostic and therapeutic context of NSC 29027

• Gas chromatography/ mass spectrometry and liquid chromatography/mass spectrometry/mass spectrometry techniques were used to identify two isomeric nonachlorohydroxybiphenylethers as major products and 2,3,5,6-tetrachloro-1,4-hydroquinone and tetrachlorocatechol as minor products [5].

References