Disease relevance of sodium iopodate

• We describe 4 patients with severe destruction-induced thyrotoxicosis who had a rapid clinical response to oral sodium ipodate (500 mg daily) [1].
• Long term treatment of Graves' hyperthyroidism with sodium ipodate [2].
• Treatment of neonatal hyperthyroidism due to Graves' disease with sodium ipodate [3].
• Five hyperthyroid patients (two men and three women) with typical features of subacute thyroiditis were treated with sodium ipodate (Oragrafin; 0.5 g, orally daily or every other day) for 15-60 days; the treatment was stopped when both serum T4 and T3 levels were normal [4].
• Gallbladder contraction and hormone release were measured in six healthy volunteers after their ingestion of two commercially available fatty meals (Biloptin Fatty Meal and Sorbitract) and intravenous bolus injection of 1 Ivy Dog Unit/kg body weight cholecystokinin (CCK) to compare the effectiveness of fatty meals to CCK [5].

Psychiatry related information on sodium iopodate

• Male rats made hypothyroid by administration of propylthiouracil plus sodium ipodate in drinking water were compared to controls in terms of period of circadian activity and temperature rhythms, amount of gross motor activity, and mean temperature [6].

High impact information on sodium iopodate

• The rates of absorption of the more polar contrast agents (tyropanoate, iopronic acid, and iocetamic acid) were greater than the less polar compounds (iopanoic acid, sodium ipodate, and calcium ipodate) under the conditions in which the resistance of the unstirred water layer is not rate limiting and where bile acid micelles are not present [7].
• We describe here five cardiac patients with type II amiodarone-induced hyperthyroidism who were treated prospectively with a combination of an oral cholecystographic agent (sodium ipodate, Oragrafin, or sodium iopanoate, Telepaque) and a thionamide (propylthiouracil or methimazole); amiodarone was discontinued in all patients [8].
• Oral administration of sodium ipodate (Oragrafin; 3 g) to two hyperthyroid patients was associated with a 76-190% increase in serum T3S at 8 h, followed by a gradual decrease to a nadir that was 25-60% of the baseline value 2-3 days after ipodate ingestion [9].
• To assess the metabolic effects of T4 and T3, we measured serum total T4 (TT4), free T4 (FT4), total T3 (TT3), TSH, and basal oxygen uptake (VO2) in eight normal subjects in the basal state and after treatment with L-T3 (T3) and sodium ipodate for 2 weeks [10].
• A study of cardiac effects of thyroid hormones: evidence for amelioration of the effects of thyroxine by sodium ipodate [11].

Chemical compound and disease context of sodium iopodate

• Treatment of hyperthyroidism with sodium ipodate (oragrafin) in addition to propylthiouracil and propranolol [12].
• We have evaluated three regimens for the rapid control (10 days' therapy) of thyrotoxicosis in hyperthyroid Graves' disease: methimazole (MMI, 40 mg/day), MMI and sodium ipodate (MMI + Na Ipodate, 1 g/day and MMI and saturated solution of potassium iodide (MMI + SSKI, 6 drops twice daily) [13].
• To investigate the effect of the combination of dexamethasone (Dex) and sodium ipodate (SI) on hyperthyroidism, we studied 24 patients with typical Graves' disease, divided into four groups of six persons each [14].

Anatomical context of sodium iopodate

• 7. Apparently, the process of the conjugation of ipodate-sodium in the mucosal cells is involved in the transfer of the 125I-radioactivity across the mucosal epithelium [15].
• The effect of injection of a cholecystokinetic agent, Ceruletide, was compared with that of the fatty meal following a single dose of Biloptin, and Biloptin with Solubiloptin, in regard to efficiency of gall-bladder contraction, cystic and common bile duct visualisation and side effects [16].

Associations of sodium iopodate with other chemical compounds

• The biliary and urinary excretion of sodium tyropanoate (Bilopaque) and sodium ipodate (Oragrafin) were studied in unanesthetized bile-fistula dogs using stepwise, increasing, intravenous infusions of the contrast materials [17].
• Locetamic acid (Cholebrine) and ipodate sodium (Oragrafin) were compared in a double blind study of 503 patients [18].

Analytical, diagnostic and therapeutic context of sodium iopodate

• Ten patients with hyperthyroidism due to Graves' disease were treated with sodium ipodate (1 g daily) in addition to propranolol (P) plus propylthiouracil (PTU; 100 mg every 8 h) and were compared with a control group of 8 patients treated with P and PTU [12].
• A new one-day medication schedule for single-visit oral cholecystography is described, using both Telepaque (iopanoic acid) tablets and Oragrafin Sodium (sodium ipodate) capsules [19].
• At 14 weeks the patient underwent a total thyroidectomy after rendering her euthyroid with a short course of sodium ipodate [20].

References