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Chemical Compound Review

AC1L3TOQ     2-(3-methylaminopropylamino) ethanethiol

Synonyms: WR-255591, AKOS006359467, WR 255591, 117062-90-5, S-2-(3-Methylaminopropylamino)ethanethiol, ...
 
 
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High impact information on WR 255591

  • The effects of the thiols cysteamine, WR-1065, and WR-255591 on radiation-induced micronucleus (MN) frequency and cell killing were compared in cultured Chinese hamster ovary cells [1].
  • Radioprotection of cultured mammalian cells by the aminothiols WR-1065 and WR-255591: correlation between protection against DNA double-strand breaks and cell killing after gamma radiation [2].
  • The observation of lower PFs for DNA strand breaks than for cell survival suggests that radioprotection by WR-255591 probably does not result from a uniform decrease in the induction of all types of DNA lesions [3].

References

  1. Effect of thiols on micronucleus frequency in gamma-irradiated mammalian cells. Murray, D., Prager, A., Altschuler, E.M., Brock, W.A. Mutat. Res. (1991) [Pubmed]
  2. Radioprotection of cultured mammalian cells by the aminothiols WR-1065 and WR-255591: correlation between protection against DNA double-strand breaks and cell killing after gamma radiation. Murray, D., Prager, A., Milas, L. Radiat. Res. (1989) [Pubmed]
  3. Radioprotection of cultured Chinese hamster ovary cells by WR-255591. Murray, D., Altschuler, E.M., Kerr, M.S., Vanankeren, S.C., Meyn, R.E., Milas, L. Int. J. Radiat. Biol. (1988) [Pubmed]
 
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