Disease relevance of MAGNESIUM HYDROXIDE

• To determine if the common practice of giving antacids to patients on salicylate therapy has an effect on serum salicylate concentrations, we gave a widely used antacid, aluminum and magnesium hydroxide, and aspirin concomitantly to three children with rheumatic fever [1].
• These results indicate a significant and equally adverse effect of smoking on the healing rate of duodenal ulcer achieved by either cimetidine or Mylanta II [2].
• Comparative efficacy of cimetidine, famotidine, ranitidine, and mylanta in postoperative stress ulcers. Gastric pH control and ulcer prevention in patients undergoing coronary artery bypass graft surgery [3].
• The treatment of chronic idiopathic constipation consisted of education, faecal disimpaction, prevention of future impaction, and promotion of regular bowel habits with dietary fibre and milk of magnesia, and finally toilet training of the preschool child [4].
• In the groups receiving magnesium hydroxide and MAM acetate, the incidence of colon neoplasms was decreased when compared with that in the group given MAM acetate alone [5].

Psychiatry related information on MAGNESIUM HYDROXIDE

• The pediatric forum: hypermagnesemia with lethargy and hypotonia due to administration of magnesium hydroxide to a 4-week-old infant [6].
• The sequence included: (1) positive reinforcement of bowel movements and the non-occurrence of soiling accidents; (2) self-evaluation; (3) positive practice; (4) milk of magnesia; (5) diet modifications; and (6) a numbered underwear strategy [7].

High impact information on MAGNESIUM HYDROXIDE

• The rate of gastric emptying of two antacids, magaldrate and Maalox, was investigated using scintigraphy [8].
• Equivalent neutralising doses of magnesium hydroxide (pH 9-4) did not increase serum gastrin and gastric acid output above basal levels, whereas antral acidification with 20 ml 0-1 N HCl resulted in a slight decrease in serum gastrin [9].
• Ten healthy male subjects ingested 25 mg of chlordiazepoxide hydrochloride (Librium) with 100 ml of water or with 100 ml of magnesium and aluminum hydroxide (Maalox) in a single-dose crossover study [10].
• Lack of effect of omeprazole or of an aluminium hydroxide/magnesium hydroxide antacid on the pharmacokinetics of lumiracoxib [11].
• The results suggest that magnesium hydroxide might exert anti-carcinogenic effects as does calcium by reducing increased cell proliferation of colonic epithelium induced by toxic effects of bile acids, which are regarded as colon tumor promoters or cocarcinogens [12].

Chemical compound and disease context of MAGNESIUM HYDROXIDE

• Acid secretory responses and parietal cell sensitivity (PCS) have been studied in 21 duodenal ulcer patients before and after successful treatment with omeprazole (n = 7), sucralfate (n = 7), or Maalox (n = 7) [13].
• Onset of action during on-demand treatment with maalox suspension or low-dose ranitidine for heartburn [14].
• Of 100 children treated with milk of magnesia or polyethylene glycol 3350 without electrolytes, 93 children underwent follow-up examinations, and the constipation was resolved with treatment in 92% of the children [15].
• Under our culture conditions, nemalite and chrysotile increased the expression of the cytokeratin-13, a specific marker of squamous metaplasia, whereas nemalite was the only particle able to strongly induce the formation of cross-linked envelopes [16].
• We examined the effectiveness of chlorthalidone or magnesium hydroxide in the prevention of recurrent calcium oxalate kidney calculi [17].

Biological context of MAGNESIUM HYDROXIDE

• The present study was designed to determine the effects of an antacid suspension containing magnesium hydroxide and aluminum hydroxide (30 ml of Maalox) on the oral bioavailability of rufloxacin (400 mg) [18].
• Twelve healthy adult male volunteers participated in a randomized, four-way crossover trial to evaluate the influence of an aluminum-magnesium antacid (Maalox; 20 ml) on the pharmacokinetics of cefixime (400 mg) [19].
• Combination with Maalox 70 caused a reduction in the AUC from 14.0 +/- 3.9 to 8.44 +/- 1.85 mg.h/liter [20].
• By means of high pressure liquid chromatography on magnesium hydroxide, wax esters and steryl esters from the skin surface lipids of human, rat and monkey were separated completely and without hydrolysis [21].
• Miniheparin therapy was continued for 3 months postpartum, followed by long-term aspirin and Ascriptin therapy [22].

Anatomical context of MAGNESIUM HYDROXIDE

• We conclude that Maalox 70 and Al(OH)3 protect the gastric mucosa against ethanol damage but that this protection requires the presence of acid and may not depend entirely upon the mucosal production of PG [23].
• Macroscopic and histologic evidence of binding by acidified Maalox to the hamster antral mucosa was clearly evident [24].
• Such an inhibitory effect on the DNA synthesis of the epithelial cells by magnesium hydroxide may be related to the suppressive action of the trace element on the carcinogen-induced large bowel carcinogenesis [25].
• This study suggest that gastroprotective agents such sucralfate and Maalox, but not sofalcone or De-Nol, activate the NO system that may contribute to mucosal integrity and preservation of mucosal microcirculation [26].
• Removal of salivary glands, the major source of EGF, also prolonged ulcer healing but, again, Maalox was as effective in ulcer healing as in rats with intact salivary glands [27].

Associations of MAGNESIUM HYDROXIDE with other chemical compounds

• The objectives of this study were to characterize the pharmacokinetics of cefpodoxime proxetil in two different oral doses and to examine possible interactions with an antacid, aluminum magnesium hydroxide (Maalox 70), and an H2 receptor antagonist, famotidine [20].
• Inhibitory effect of magnesium hydroxide on methylazoxymethanol acetate-induced large bowel carcinogenesis in male F344 rats [5].
• The effect of an antacid drug (Maalox 70) on the pharmacokinetics of temafloxacin was studied in 12 healthy young volunteers [28].
• The bioavailability of a single oral 400-mg enoxacin dose was significantly decreased, by 73 and 49%, when Maalox TC was administered 0.5 and 2 h before enoxacin, respectively [29].
• For the cis isomer, bioavailability point estimates (90% confidence intervals) of the mean Cmax and AUG0-infinity values for the Maalox treatment relative to those for the reference treatment were 95% (87%, 103%) and 99% (95%, 104%), respectively [30].

Gene context of MAGNESIUM HYDROXIDE

• Acid rebound and gastrin release will also be induced in duodenal ulcer patients by magnesium hydroxide [31].
• Mylanta Lemon Twist and Mylanta Cherry Crème were the most palatable antacids; however, overall the palatability of all the antacids was poor [32].
• Maalox MS Cool Mint and ES Gaviscon were the least palatable [32].
• 8. The zeta-potential of magnesium hydroxide below this pH was positive [33].
• These results suggest that the anti-carcinogenic effect of magnesium hydroxide on rat colon carcinogenesis induced by MAM acetate may be related to the inhibition of the carcinogen-induced expression of c-myc proto-oncogene and cell proliferation [34].

Analytical, diagnostic and therapeutic context of MAGNESIUM HYDROXIDE

• In an effort to reduce the ingestion of aluminum in phosphate-binding antacids, we treated seven patients on continuous ambulatory peritoneal dialysis (CAPD) with low magnesium dialysate and phosphate binders containing both aluminum and magnesium hydroxide [35].
• Milk of magnesia is an effective preinduction antacid in obstetric anesthesia [36].
• Efficacy was determined by pre- and poststudy endoscopies, symptom assessments by patient and physician, and Maalox consumption [37].
• Four of the patients then received 20 mg SOS with 30 cc of liquid antacid (Mylanta) per gastrostomy o.d. for a further 7 days and then underwent a third pH study [38].
• The results of the 27Al NMR and pH-stat titrations are consistent with the hypotheses that magaldrate is a homogeneous substance with a hydrotalcite-like structure and that mixed gels consist of a magnesium hydroxide core surrounded by aluminum hydroxide [39].

References