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Chemical Compound Review

Nemalite     magnesium dihydroxide

Synonyms: Versamag, Reachim, Kudrox, Milmag, Duhor, ...
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Disease relevance of MAGNESIUM HYDROXIDE


Psychiatry related information on MAGNESIUM HYDROXIDE


High impact information on MAGNESIUM HYDROXIDE


Chemical compound and disease context of MAGNESIUM HYDROXIDE


Biological context of MAGNESIUM HYDROXIDE


Anatomical context of MAGNESIUM HYDROXIDE

  • We conclude that Maalox 70 and Al(OH)3 protect the gastric mucosa against ethanol damage but that this protection requires the presence of acid and may not depend entirely upon the mucosal production of PG [23].
  • Macroscopic and histologic evidence of binding by acidified Maalox to the hamster antral mucosa was clearly evident [24].
  • Such an inhibitory effect on the DNA synthesis of the epithelial cells by magnesium hydroxide may be related to the suppressive action of the trace element on the carcinogen-induced large bowel carcinogenesis [25].
  • This study suggest that gastroprotective agents such sucralfate and Maalox, but not sofalcone or De-Nol, activate the NO system that may contribute to mucosal integrity and preservation of mucosal microcirculation [26].
  • Removal of salivary glands, the major source of EGF, also prolonged ulcer healing but, again, Maalox was as effective in ulcer healing as in rats with intact salivary glands [27].

Associations of MAGNESIUM HYDROXIDE with other chemical compounds




Analytical, diagnostic and therapeutic context of MAGNESIUM HYDROXIDE


  1. Decreased serum salicylate concentrations in children with rheumatic fever treated with antacid. Levy, G., Lampman, T., Kamath, B.L., Garrettson, L.K. N. Engl. J. Med. (1975) [Pubmed]
  2. Influence of smoking on healing rate of duodenal ulcer in response to cimetidine or high-dose antacid. Korman, M.G., Shaw, R.G., Hansky, J., Schmidt, G.T., Stern, A.I. Gastroenterology (1981) [Pubmed]
  3. Comparative efficacy of cimetidine, famotidine, ranitidine, and mylanta in postoperative stress ulcers. Gastric pH control and ulcer prevention in patients undergoing coronary artery bypass graft surgery. Lamothe, P.H., Rao, E., Serra, A.J., Castellano, J., Woronick, C.L., McNicholas, K.W., Lemole, G.M. Gastroenterology (1991) [Pubmed]
  4. Constipation in early childhood: patient characteristics, treatment, and longterm follow up. Loening-Baucke, V. Gut (1993) [Pubmed]
  5. Inhibitory effect of magnesium hydroxide on methylazoxymethanol acetate-induced large bowel carcinogenesis in male F344 rats. Tanaka, T., Shinoda, T., Yoshimi, N., Niwa, K., Iwata, H., Mori, H. Carcinogenesis (1989) [Pubmed]
  6. The pediatric forum: hypermagnesemia with lethargy and hypotonia due to administration of magnesium hydroxide to a 4-week-old infant. Sullivan, J.E., Berman, B.W. Archives of pediatrics & adolescent medicine. (2000) [Pubmed]
  7. Enhancing the management of secondary encopresis by assessing acceptability of treatment: a case study. Steege, M.W., Harper, D.C. Journal of behavior therapy and experimental psychiatry. (1989) [Pubmed]
  8. Gastric emptying of two radiolabelled antacids. Monés, J., Carrió, I., Roca, M., Estorch, M., Calabuig, R., Sainz, S., Martinez-Duncker, C., Vilardell, F. Gut (1991) [Pubmed]
  9. Calcium stimulation of gastrin and gastric acid secretion: effect of small doses of calcium carbonate. Behar, J., Hitchings, M., Smyth, R.D. Gut (1977) [Pubmed]
  10. Influence of magnesium and aluminum hydroxide mixture on chlordiazepoxide absorption. Greenblatt, D.J., Shader, R.I., Harmatz, J.S., Franke, K., Koch-Weser, J. Clin. Pharmacol. Ther. (1976) [Pubmed]
  11. Lack of effect of omeprazole or of an aluminium hydroxide/magnesium hydroxide antacid on the pharmacokinetics of lumiracoxib. Scott, G., Vinluan Reynolds, C., Milosavljev, S., Langholff, W., Shenouda, M., Rordorf, C. Clinical pharmacokinetics. (2004) [Pubmed]
  12. The inhibitory effect of magnesium hydroxide on the bile acid-induced cell proliferation of colon epithelium in rats with comparison to the action of calcium lactate. Wang, A., Yoshimi, N., Tanaka, T., Mori, H. Carcinogenesis (1994) [Pubmed]
  13. Acid secretory responses and parietal cell sensitivity following duodenal ulcer healing with omeprazole, sucralfate, and Maalox. Johnston, D.A., Marks, I.N., Young, G.O., Tigler-Wybrandi, N.A., Bridger, S., Zak, J. Am. J. Med. (1991) [Pubmed]
  14. Onset of action during on-demand treatment with maalox suspension or low-dose ranitidine for heartburn. Faaij, R.A., Van Gerven, J.M., Jolivet-Landreau, I., Masclee, A.A., Vendrig, E.M., Schoemaker, R.C., Jacobs, L.D., Cohen, A.F. Aliment. Pharmacol. Ther. (1999) [Pubmed]
  15. Prevalence, symptoms and outcome of constipation in infants and toddlers. Loening-Baucke, V. J. Pediatr. (2005) [Pubmed]
  16. Effect of mineral particles containing iron on primary cultures of rabbit tracheal epithelial cells: possible implication of oxidative stress. Guilianelli, C., Baeza-Squiban, A., Boisvieux-Ulrich, E., Houcine, O., Zalma, R., Guennou, C., Pezerat, H., Marano, F. Environ. Health Perspect. (1993) [Pubmed]
  17. Chlorthalidone reduces calcium oxalate calculous recurrence but magnesium hydroxide does not. Ettinger, B., Citron, J.T., Livermore, B., Dolman, L.I. J. Urol. (1988) [Pubmed]
  18. Effects of magnesium-aluminum hydroxide antacid on absorption of rufloxacin. Lazzaroni, M., Imbimbo, B.P., Bargiggia, S., Sangaletti, O., Dal Bo, L., Broccali, G., Porro, G.B. Antimicrob. Agents Chemother. (1993) [Pubmed]
  19. Influence of an antacid containing aluminum and magnesium on the pharmacokinetics of cefixime. Healy, D.P., Sahai, J.V., Sterling, L.P., Racht, E.M. Antimicrob. Agents Chemother. (1989) [Pubmed]
  20. Pharmacokinetics of cefpodoxime proxetil and interactions with an antacid and an H2 receptor antagonist. Saathoff, N., Lode, H., Neider, K., Depperman, K.M., Borner, K., Koeppe, P. Antimicrob. Agents Chemother. (1992) [Pubmed]
  21. Separation of wax esters from steryl esters by chromatography on magnesium hydroxide. Stewart, M.E., Downing, D.T. Lipids (1981) [Pubmed]
  22. Management of deep venous thrombosis and pulmonary embolism during pregnancy. Tawes, R.L., Kennedy, P.A., Harris, E.J., Brown, W.H., Scribner, R.G., Sydorak, G.R., Beare, J.P. Am. J. Surg. (1982) [Pubmed]
  23. Role of intragastric pH in cytoprotection by antacids in rats. Konturek, S.J., Brzozowski, T., Drozdowicz, D., Nauert, C. Eur. J. Pharmacol. (1990) [Pubmed]
  24. Protection by acidified Maalox against indomethacin-induced gastric antral ulceration in hamsters. Fitzpatrick, L.R. Digestion (1991) [Pubmed]
  25. Effect of magnesium hydroxide on methylazoxymethanol acetate-induced epithelial proliferation in the large bowels of rats. Mori, H., Morishita, Y., Mori, Y., Yoshimi, N., Sugie, S., Tanaka, T. Cancer Lett. (1992) [Pubmed]
  26. Implications of nitric oxide in the action of cytoprotective drugs on gastric mucosa. Konturek, S.J., Brzozowski, T., Majka, J., Szlachcic, A., Pytko-Polonczyk, J. J. Clin. Gastroenterol. (1993) [Pubmed]
  27. Healing of chronic gastroduodenal ulcerations by antacids. Role of prostaglandins and epidermal growth factor. Konturek, S.J., Brzozowski, T., Drozdowicz, D., Dembinski, A., Nauert, C. Dig. Dis. Sci. (1990) [Pubmed]
  28. Effect of antacid medication on the pharmacokinetics of temafloxacin. Granneman, G.R., Stephan, U., Birner, B., Sörgel, F., Mukherjee, D. Clinical pharmacokinetics. (1992) [Pubmed]
  29. Inhibition of enoxacin absorption by antacids or ranitidine. Grasela, T.H., Schentag, J.J., Sedman, A.J., Wilton, J.H., Thomas, D.J., Schultz, R.W., Lebsack, M.E., Kinkel, A.W. Antimicrob. Agents Chemother. (1989) [Pubmed]
  30. Effect of antacid on the bioavailability of cefprozil. Shyu, W.C., Wilber, R.B., Pittman, K.A., Barbhaiya, R.H. Antimicrob. Agents Chemother. (1992) [Pubmed]
  31. Antacids and hormones. Holtermüller, K.H., Dehdaschti, M. Scand. J. Gastroenterol. Suppl. (1982) [Pubmed]
  32. Comparative palatability of 22 liquid antacids. Temple, M.E., Nahata, M.C. Aliment. Pharmacol. Ther. (2000) [Pubmed]
  33. Electrokinetic studies of magnesium hydroxide. Schott, H. Journal of pharmaceutical sciences. (1981) [Pubmed]
  34. Inhibitory effects of magnesium hydroxide on c-myc expression and cell proliferation induced by methylazoxymethanol acetate in rat colon. Wang, A., Yoshimi, N., Tanaka, T., Mori, H. Cancer Lett. (1993) [Pubmed]
  35. Use of magnesium hydroxide and low magnesium dialysate does not permit reduction of aluminum hydroxide during continuous ambulatory peritoneal dialysis. Jennings, A.E., Bodvarsson, M., Galicka-Piskorska, G., Diefendorf, A.S., Simon, G.M., Levey, A.S. Am. J. Kidney Dis. (1986) [Pubmed]
  36. Milk of magnesia is an effective preinduction antacid in obstetric anesthesia. Wheatley, R.G., Kallus, F.T., Reynolds, R.C., Giesecke, A.H. Anesthesiology (1979) [Pubmed]
  37. Cisapride for gastroesophageal reflux disease: a placebo-controlled, double-blind study. Richter, J.E., Long, J.F. Am. J. Gastroenterol. (1995) [Pubmed]
  38. The effects on intragastric acidity of per-gastrostomy administration of an alkaline suspension of omeprazole. Sharma, V.K., Vasudeva, R., Howden, C.W. Aliment. Pharmacol. Ther. (1999) [Pubmed]
  39. Action of hydrochloric acid on aluminum hydroxide-magnesium hydroxide gels and magaldrate: 27Al NMR and pH-stat studies. Wilson, G.E., Falzone, C.J., Johnson, R., Lee, H.K. Journal of pharmaceutical sciences. (1985) [Pubmed]
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