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Chemical Compound Review:

Xeroform 2,4,6-tribromophenol

Synonyms: Bromol, Tribromophenol, Flammex 3BP, SureCN18224, Bromkal pur 3, ...

Chung, H.Y. et al., Olsen, C.M. et al., Richard, A.M., Boyle, A.W. et al., Nejidat, A. et al., et al.

Richard, Chung, Ma, Ang, Kim, Chen, Arnon, Ronen, Adar, Yakirevich, Nativ, Olsen, Meussen-Elholm, Holme, Hongslo, Nejidat, Saadi, Ronen,

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Disease relevance of Bromol

AIM: To investigate the factors governing the adhesion and activity of the 2,4,6-tribromophenol (TBP) degrading bacterium Achromobacter piechaudii TBPZ-N61 on chalk from a contaminated aquifer [1].
We have characterized the estrogen-like activity of phenol, 4-bromophenol (4-BP), 2,4-dibromophenol (2,4-DBP), 2,4,6-tribromophenol (2,4,6-TBP) and 4-tert-butylphenol (tert-BP) using the estrogen-dependent human breast cancer cell line MCF-7 [2].

High impact information on Bromol

Strain TBP-1, an anaerobic bacterium capable of reductively dehalogenating 2,4,6-tribromophenol to phenol, was isolated from estuarine sediments of the Arthur Kill in the New York/New Jersey harbor [3].
The marine secondary metabolites 2,4-dibromophenol and 2,4,6-tribromophenol differentially modulate voltage dependent ion currents in neuroendocrine (PC12) cells [4].
The transmissivity of the fractures was continuously reduced due to biomass accumulation in the fracture concurrent with TBP biodegradation [5].
Distributions and seasonal variations of the key seafood flavor compounds including 2-bromophenol, 4-bromophenol, 2,4-dibromophenol, 2,6-dibromophenol, and 2,4,6-tribromophenol in three species of brown algae (Padina arborescens, Sargassum siliquastrum, and Lobophora variegata) found in Hong Kong waters were investigated [6].
Pregnant Wistar rats were exposed to 2,4,6-Tribromophenol (TBP) by whole body inhalation (0, 0.03, 0.1, 0.3, 1.0 mg/m3, 24 hr/day, 7 days/weeks, from day 1 to 21 of gestation) [7].

Biological context of Bromol

Two recent examples (an EPA testing prioritization exercise for water disinfection byproducts and a regulatory action on 2,4,6-tribromophenol) illustrate issues involved in regulatory applications of SAR and commercial prediction systems [8].

References

Degradation of 2,4,6-tribromophenol by bacterial cells attached to chalk collected from a contaminated aquifer. Nejidat, A., Saadi, I., Ronen, Z. J. Appl. Microbiol. (2004) [Pubmed]
Brominated phenols: characterization of estrogen-like activity in the human breast cancer cell-line MCF-7. Olsen, C.M., Meussen-Elholm, E.T., Holme, J.A., Hongslo, J.K. Toxicol. Lett. (2002) [Pubmed]
Isolation from estuarine sediments of a Desulfovibrio strain which can grow on lactate coupled to the reductive dehalogenation of 2,4, 6-tribromophenol. Boyle, A.W., Phelps, C.D., Young, L.Y. Appl. Environ. Microbiol. (1999) [Pubmed]
The marine secondary metabolites 2,4-dibromophenol and 2,4,6-tribromophenol differentially modulate voltage dependent ion currents in neuroendocrine (PC12) cells. Hassenklöver, T., Bickmeyer, U. Aquat. Toxicol. (2006) [Pubmed]
Two-dimensional distribution of microbial activity and flow patterns within naturally fractured chalk. Arnon, S., Ronen, Z., Adar, E., Yakirevich, A., Nativ, R. J. Contam. Hydrol. (2005) [Pubmed]
Seasonal variations of bromophenols in brown algae (Padina arborescens, Sargassum siliquastrum, and Lobophora variegata) collected in Hong Kong. Chung, H.Y., Ma, W.C., Ang, P.O., Kim, J.S., Chen, F. J. Agric. Food Chem. (2003) [Pubmed]
Developmental neurotoxicity and immunotoxicity of 2,4,6-tribromophenol in Wistar rats. Lyubimov, A.V., Babin, V.V., Kartashov, A.I. Neurotoxicology (1998) [Pubmed]
Commercial toxicology prediction systems: a regulatory perspective. Richard, A.M. Toxicol. Lett. (1998) [Pubmed]

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