Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

C10409 [(7R,8R)-7-(2-methylbut-2- enoyloxy)-5,6,7...

Synonyms:

Kim, N.C. et al., Hirono, I. et al.

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High impact information on C10409

Group II received ip injections of symphytine at a dose of 10% of the LD50 by the same injection schedule as in group I. The control group was given ip injections of a 0.9% NaCl solution following the same injection schedule as in experimental groups [1].
Three pyrrolizidine alkaloids, symlandine, symphytine, and echimidine (1-3), were isolated from the roots of Symphytum officinale using a one-step countercurrent chromatography procedure [2].

Analytical, diagnostic and therapeutic context of C10409

Isolation of symlandine from the roots of common comfrey (Symphytum officinale) using countercurrent chromatography [2].

References

Induction of hepatic tumors in rats by senkirkine and symphytine. Hirono, I., Haga, M., Fujii, M., Matsuura, S., Matsubara, N., Nakayama, M., Furuya, T., Hikichi, M., Takanashi, H., Uchida, E., Hosaka, S., Ueno, I. J. Natl. Cancer Inst. (1979) [Pubmed]
Isolation of symlandine from the roots of common comfrey (Symphytum officinale) using countercurrent chromatography. Kim, N.C., Oberlies, N.H., Brine, D.R., Handy, R.W., Wani, M.C., Wall, M.E. J. Nat. Prod. (2001) [Pubmed]

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