Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

gamma-Glu-gln (2S)-2-amino-4-[[(1S)-3- aminocarbonyl-1...

Synonyms: AG-D-91065, CHEBI:73707, HMDB11738, CTK4C5039, AC1L459X, ...

Li, X. et al., Andiné, P. et al., Hammond, J.W. et al.

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Disease relevance of gamma-Glu-gln

Extracellular cysteate, cysteine sulfinate, and gamma-glutamyltaurine increased (1.5- to threefold) during ischemia, and extracellular glutathione and gamma-glutamylaspartate plus gamma-glutamylglutamine increased during early reflow (two- to threefold) [1].

High impact information on gamma-Glu-gln

The concentrations of gamma-glutamylglutamate, gamma-glutamylglutamine, gamma-glutamylcysteine, glutamate, aspartate, glutamine, cyst(e)ine and glutathione (including disulfides) were determined by HPLC analysis of both the tissue and the surrounding medium of incubated rat hippocampal slices [2].
gamma-Glutamylglutamine identified in plasma and cerebrospinal fluid from hyperammonaemic patients [3].

References

Extracellular acidic sulfur-containing amino acids and gamma-glutamyl peptides in global ischemia: postischemic recovery of neuronal activity is paralleled by a tetrodotoxin-sensitive increase in cysteine sulfinate in the CA1 of the rat hippocampus. Andiné, P., Orwar, O., Jacobson, I., Sandberg, M., Hagberg, H. J. Neurochem. (1991) [Pubmed]
Gamma-glutamyl peptides and related amino acids in rat hippocampus in vitro: effect of depolarization and gamma-glutamyl transpeptidase inhibition. Li, X., Orwar, O., Revesjö, C., Sandberg, M. Neurochem. Int. (1996) [Pubmed]
gamma-Glutamylglutamine identified in plasma and cerebrospinal fluid from hyperammonaemic patients. Hammond, J.W., Potter, M., Truscott, R., Wilcken, B. Clin. Chim. Acta (1990) [Pubmed]

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