Disease relevance of Acetylenic acid

• Effect of 2-hexadecynoic acid on cultured 7288C hepatoma cells [1].
• 2,6-Hexadecadiynoic acid and 2-hexadecynoic acid also displayed a MIC of 140-145 microM toward Mycobacterium tuberculosis H37Rv in Middlebrook 7H12 medium [2].
• Methyl 2-hexadecynoate caused a 25% decrease in body weight and the appearance of essential fatty acid deficiency symptoms within one week [3].

High impact information on Acetylenic acid

• When added to the culture medium, 2-hexadecynoic acid inhibited the growth of HeLa cells, but when mixed with an equivalent amount of palmitic acid, growth inhibition was not observed [4].
• The 2-hexadecynoic acid inhibited lipid metabolism of the HTC cells at least at two levels [1].
• Growth was inhibited by the acetylenic acid: the LD50 was 35-85 microM as determined by two methods at low and high cell densities [1].
• Normal and hepatoma bearing rats were fed a low level of methyl 2-hexadecynoate in a low fat diet for one month [3].

Chemical compound and disease context of Acetylenic acid

• In contrast to host liver and hepatoma, methyl 2-hexadecynoate caused a massive accumulation of palmitate and hexadecenoates with a concomitant decrease in stearate and octadecenoates in most of the lipid classes from non-tumor-bearing animals [3].

References