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Chemical Compound Review:

HCFC-132b 1,2-dichloro-1,1-difluoro- ethane

Synonyms: LS-921, AG-E-14562, HSDB 6758, KB-64293, CTK1E2278, ...

Surbrook, S.E. et al., Yin, H. et al., Harris, J.W. et al.

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Disease relevance of HSDB 6758

In rat and rabbit, the P-450 form 2E1 is a predominant low-KM, high-rate catalyst of HFC-134a biotransformation and is prominently involved in the metabolism of other tetrahaloalkanes of greater toxicity than HFC-134a [e.g. 1,2-dichloro-1,1-difluoroethane (HCFC-132b)] [1].

High impact information on HSDB 6758

Male Fischer 344 rats were given 10 mmol/kg ip HCFC-131a or HCFC-132b or exposed by inhalation to 1% HCFC-133a for 2 h [2].

Analytical, diagnostic and therapeutic context of HSDB 6758

Male Fischer 344 rats were given 10 mmol/kg HCFC-132b dissolved in corn oil by intraperitoneal injection [3].

References

Dominant role of cytochrome P-450 2E1 in human hepatic microsomal oxidation of the CFC-substitute 1,1,1,2-tetrafluoroethane. Surbrook, S.E., Olson, M.J. Drug Metab. Dispos. (1992) [Pubmed]
Metabolism of 1-fluoro-1,1,2-trichloroethane, 1,2-dichloro-1,1-difluoroethane, and 1,1,1-trifluoro-2-chloroethane. Yin, H., Jones, J.P., Anders, M.W. Chem. Res. Toxicol. (1995) [Pubmed]
Metabolism of the hydrochlorofluorocarbon 1,2-dichloro-1,1-difluoroethane. Harris, J.W., Anders, M.W. Chem. Res. Toxicol. (1991) [Pubmed]

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