Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

Citralva (2E)-3,7-dimethylocta-2,6- dienenitrile

Synonyms: Geranonitrile, NSC-109052, NSC109052, STL371306, ZINC01701190, ...

Brain, K.R. et al., Boekhoff, I. et al., Schild, D. et al., Komori, T. et al., Hosoi, J. et al., et al.

Kemper, Nabb, Gannon, Snow, Api, Komori, Miyahara, Yamamoto, Matsumoto, Zhang, Nakagawa, Nomura, Motomura, Shiroyama, Okazaki, Hosoi, Tsuchiya,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Citralva

Glucocorticoid receptor antagonist abrogated the suppressive effect of citralva on contact hypersensitivity [1].

High impact information on Citralva

In isolated rat olfactory cilia, odorants such as citralva stimulate a burst of cAMP, which peaks in 50 ms and returns almost to base-line level within 150 ms in the continuing presence of odorant [2].
Once activated, gcat showed no further dependence upon [Ca2+]i. Icat is shown to be different from the current activated by a mixture of the odorants citralva and amyl acetate [3].
Comparative metabolism of geranyl nitrile and citronellyl nitrile in mouse, rat, and human hepatocytes [4].
In comparison, citralva restored the expression of IL-6 and IL-6R mRNAs and significantly increased serum ACTH and corticosterone levels [5].
In-vitro human skin permeation and distribution of geranyl nitrile (GN) was determined using epidermal membranes following application (5mul/cm(2)) in 70% ethanol, under non-occlusive conditions, at maximum in-use concentration (1%) [6].

References

Regulation of cutaneous allergic reaction by odorant inhalation. Hosoi, J., Tsuchiya, T. J. Invest. Dermatol. (2000) [Pubmed]
Olfactory desensitization requires membrane targeting of receptor kinase mediated by beta gamma-subunits of heterotrimeric G proteins. Boekhoff, I., Inglese, J., Schleicher, S., Koch, W.J., Lefkowitz, R.J., Breer, H. J. Biol. Chem. (1994) [Pubmed]
Amiloride-insensitive cation conductance in Xenopus laevis olfactory neurons: a combined patch clamp and calcium imaging analysis. Schild, D., Lischka, F.W. Biophys. J. (1994) [Pubmed]
Comparative metabolism of geranyl nitrile and citronellyl nitrile in mouse, rat, and human hepatocytes. Kemper, R.A., Nabb, D.L., Gannon, S.A., Snow, T.A., Api, A.M. Drug Metab. Dispos. (2006) [Pubmed]
Effects of odorants on the hypothalamic-pituitary-adrenal axis and interleukin-6 (IL-6) and IL-6 receptor mRNA expression in rat hypothalamus after restraint stress. Komori, T., Miyahara, S., Yamamoto, M., Matsumoto, T., Zhang, K., Nakagawa, M., Nomura, S., Motomura, E., Shiroyama, T., Okazaki, Y. Chem. Senses (2003) [Pubmed]
In-vitro human skin penetration of the fragrance material geranyl nitrile. Brain, K.R., Green, D.M., Lalko, J., Api, A.M. Toxicology in vitro : an international journal published in association with BIBRA (2007) [Pubmed]

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