Disease relevance of CCRIS 6759

• Reactivity with DNA bases and mutagenicity toward Salmonella typhimurium of methylchrysene diol epoxide enantiomers [1].

High impact information on CCRIS 6759

• Metabolism of 5-methylchrysene and 6-methylchrysene by human hepatic and pulmonary cytochrome P450 enzymes [2].
• The stereoselectivity of mouse skin metabolic activation to dihydrodiols of the strong carcinogen 5-methylchrysene (5-MeC) and the weak carcinogen 6-methylchrysene (6-MeC) was investigated [3].
• The conformations of adducts derived from the covalent binding of four different isomeric diol epoxide derivatives of 5- or 6-methylchrysene to native double-stranded calf thymus DNA were studied by linear dichroism techniques [4].
• Benzo[c]chrysene and to a lesser extent 6-methylchrysene were the only compounds capable of stimulating epoxide hydrolase activity, but the effect was modest [5].
• In addition, both 5-methyl- and 6-methylchrysene were found to undergo a dealkylation reaction in these tissues to yield chrysene as well as both a biooxidation reaction to yield the corresponding hydroxyalkyl substituted chrysene and a bioalkylation reaction to give a dimethyl substituted chrysene [6].

Biological context of CCRIS 6759

• Comparative metabolic activation in mouse skin of the weak carcinogen 6-methylchrysene and the strong carcinogen 5-methylchrysene [7].

Anatomical context of CCRIS 6759

• The polynuclear aromatic hydrocarbon chrysene undergoes a bioalkylation substitution reaction in vitro, in rat liver cytosol preparations, and in vivo, in rat dorsal subcutaneous tissue to yield 6-methylchrysene as a metabolite [6].

Analytical, diagnostic and therapeutic context of CCRIS 6759

• Identification of mutagenic methylbenz[a]anthracene and methylchrysene isomers in natural samples by liquid chromatography and Shpol'skii spectrometry [8].

References