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Chemical Compound Review:

Istamycin B 2-amino-N-[(1S,2R,3R,4R,6S)- 4-amino-3-[(2R...

Synonyms: AC1L4FIX, LS-84025, C17991, 72523-64-9, 78739-02-3

Hotta, K. et al., Hotta, K. et al., Ikeda, D. et al.

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Disease relevance of Istamycin B

The authors attempted to prepare the derivatives of istamycin B having high potency and low toxicity [1].

High impact information on Istamycin B

None of astromicin (ASTM)-group AGs tested (ASTM and istamycin B) retained activity after acetylation by AAC(2') and AAC(6') [2].

Biological context of Istamycin B

Interestingly, the acetylation of istamycin B (ISM-B; an ASTM group AG) resulted in the formation of two different products (1-N-acetyl ISM-B and 2"-N-acetyl ISM-B) at a similar ratio [3].

References

Low toxic derivatives of istamycin B: synthesis and preliminary evaluation. Ikeda, D., Gomi, S., Hamada, M., Kondo, S., Takeuchi, T. Drugs under experimental and clinical research. (1992) [Pubmed]
Double stage activity in aminoglycoside antibiotics. Hotta, K., Sunada, A., Ikeda, Y., Kondo, S. J. Antibiot. (2000) [Pubmed]
Mechanism of multiple aminoglycoside resistance of kasugamycin-producing Streptomyces kasugaensis MB273: involvement of two types of acetyltransferases in resistance to astromicin group antibiotics. Hotta, K., Ogata, T., Ishikawa, J., Okanishi, M., Mizuno, S., Morioka, M., Naganawa, H., Okami, Y. J. Antibiot. (1996) [Pubmed]

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