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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Chemical Compound Review

Calmeran     diphenyl-(4-piperidyl)methanol

Synonyms: Frenoton, Frenquel, Ataractan, Psychosan, Azacyclonol, ...
 
 
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High impact information on Frenquel

  • The concentrations of fexofenadine and its metabolite, azacyclonol, were quantified in serum and urine by liquid chromatography-mass spectrometry [1].
  • The amount of azacyclonol, a CYP3A4 mediated metabolite of fexofenadine, eliminated renally increased on average 2-fold after rifampin dosing; however, this pathway accounted for less than 0.5% of the dose [2].
  • Measurement of azacyclonol in urine and serum of humans following terfenadine (Seldane) administration using gas chromatography-mass spectrometry [3].

References

  1. The effect of short- and long-term administration of verapamil on the disposition of cytochrome P450 3A and P-glycoprotein substrates. Lemma, G.L., Wang, Z., Hamman, M.A., Zaheer, N.A., Gorski, J.C., Hall, S.D. Clin. Pharmacol. Ther. (2006) [Pubmed]
  2. The effect of rifampin administration on the disposition of fexofenadine. Hamman, M.A., Bruce, M.A., Haehner-Daniels, B.D., Hall, S.D. Clin. Pharmacol. Ther. (2001) [Pubmed]
  3. Measurement of azacyclonol in urine and serum of humans following terfenadine (Seldane) administration using gas chromatography-mass spectrometry. Kuhlman, J.J., Levine, B., Klette, K.L., Magluilo, J., Kalasinsky, K.S., Smith, M.L. J. Chromatogr. (1992) [Pubmed]
 
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