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Chemical Compound Review:

TALIBEGRON 2-[4-[2-[[(2S)-2-hydroxy-2- phenyl...

Synonyms: Talibegron HCl, ICID2079, AG-E-28766, CHEMBL1354284, SureCN1230810, ...

This record was replaced with 158794.

Kozłowska, H. et al., Zelaszczyk, D. et al.

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High impact information on 2-[4-[2-[[(2R)-2-hydroxy-2-phenyl-ethyl]amino]ethoxy]phenyl]acetic acid

(5) Removal of endothelium diminished the vasorelaxant effects of cyanopindolol, CGP 12177 and ZD 2079 [1].
(2) Mesenteric arteries precontracted with phenylephrine were relaxed by beta-agonists with the following potencies (pD2): nonselective agonist isoprenaline (6.00)>nonconventional partial agonist cyanopindolol (5.45)>beta2-agonist fenoterol (4.98)>nonconventional partial agonist CGP 12177 (4.19)>beta3-agonist ZD 2079 (3.72) [1].
CL 316243 and another three beta3-adrenoceptor agonists (BRL 37344, ZD 2079 and CGP 12177) failed to affect the electrically evoked tritium overflow also in slices preincubated with 3H-noradrenaline and superfused in the presence of the alpha2-adrenoceptor antagonist rauwolscine whereas prostaglandin E2 caused a marked inhibition [2].

References

Atypical beta-adrenoceptors, different from beta 3-adrenoceptors and probably from the low-affinity state of beta 1-adrenoceptors, relax the rat isolated mesenteric artery. Kozłowska, H., Szymska, U., Schlicker, E., Malinowska, B. Br. J. Pharmacol. (2003) [Pubmed]
A search for presynaptic beta3-adrenoceptors in the rat. Zelaszczyk, D., Zakrzeska, A., Kwolek, G., Malinowska, B., Schlicker, E. Fundamental & clinical pharmacology. (2005) [Pubmed]

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