Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Chemical Compound Review:

KST-1A4206 3-[2-[(4aR,5S,8aR)-5,8a- dimethyl-2...

Synonyms: KST-1A4207, AR-1A9284, AR-1A9285, AKOS015896739, AC1L4N48, ...

Zhao, J. et al., Thisoda, P. et al., Wiart, C. et al., Qizhen, D. et al.

Wiart, Kumar, Yusof, Hamimah, Fauzi, Sulaiman,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Neoandrographolide

Andrographolide, neoandrographolide and 14-deoxy-11,12-didehydroandrographolide, ent-labdene diterpenes isolated from Andrographis paniculata showed viricidal activity against herpes simplex virus 1 (HSV-1) [1].

High impact information on Neoandrographolide

The results indicated that andrographolide (AP(1)) and 14-deoxy-11,12-didehydroandrographolide (AP(3)) significantly inhibited thrombin-induced platelet aggregation in a concentration-(1-100 muM) and time-dependent manner while neoandrographolide (AP(4)) had little or no activity [2].
The bioactive diterpenes andrographolide and neoandrographolide from the leaves of Andrographis paniculata NEES (Acanthaceae) were successfully separated by counter-current chromatography [3].

Analytical, diagnostic and therapeutic context of Neoandrographolide

In this paper a micellar electrokinetic capillary chromatographic (MEKC) method has been developed for determining the active components (andrographolide, deoxyandrographolide and neoandrographolide) in water:ethanol extracts of the Chinese crude herb Andrographis paniculata and its preparations (Chuanxinlian and Xiaoyan Lidan tablets) [4].

References

Antiviral properties of ent-labdene diterpenes of Andrographis paniculata nees, inhibitors of herpes simplex virus type 1. Wiart, C., Kumar, K., Yusof, M.Y., Hamimah, H., Fauzi, Z.M., Sulaiman, M. Phytotherapy research : PTR. (2005) [Pubmed]
Inhibitory effect of Andrographis paniculata extract and its active diterpenoids on platelet aggregation. Thisoda, P., Rangkadilok, N., Pholphana, N., Worasuttayangkurn, L., Ruchirawat, S., Satayavivad, J. Eur. J. Pharmacol. (2006) [Pubmed]
Separation of andrographolide and neoandrographolide from the leaves of Andrographis paniculata using high-speed counter-current chromatography. Qizhen, D., Jerz, G., Winterhalter, P. Journal of chromatography. A. (2003) [Pubmed]
Determination of andrographolide, deoxyandrographolide and neoandrographolide in the Chinese herb Andrographis paniculata by micellar electrokinetic capillary chromatography. Zhao, J., Yang, G., Liu, H., Wang, D., Song, X., Chen, Y. Phytochemical analysis : PCA. (2002) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.