Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

PubChem4143 4-fluorobenzene-1,2-diol

Synonyms: SureCN69524, AG-K-72957, ACMC-209ioe, ANW-28476, AC-3823, ...

Schlömann, M. et al., Carvalho, M.F. et al.

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Disease relevance of 4-Fluorocatechol

Enzymatic conversion of 4-fluorocatechol in the simultaneous presence of partially purified preparations of catechol 1,2-dioxygenase from Pseudomonas cepacia and muconate cycloisomerase from Alcaligenes eutrophus 335 yielded a product that was unambiguously identified as (+)-4-fluoromuconolactone [(+)-4-carboxymethyl-4-fluoro-but-2-en-4-olide] [1].

High impact information on 4-Fluorocatechol

Liquid chromatography-mass spectrometry analysis showed that 4-fluorocatechol and catechol were formed as intermediates during fluorobenzene degradation by cell suspensions [2].

References

Enzymatic formation, stability, and spontaneous reactions of 4-fluoromuconolactone, a metabolite of the bacterial degradation of 4-fluorobenzoate. Schlömann, M., Fischer, P., Schmidt, E., Knackmuss, H.J. J. Bacteriol. (1990) [Pubmed]
Degradation of Fluorobenzene by Rhizobiales Strain F11 via ortho Cleavage of 4-Fluorocatechol and Catechol. Carvalho, M.F., Ferreira, M.I., Moreira, I.S., Castro, P.M., Janssen, D.B. Appl. Environ. Microbiol. (2006) [Pubmed]

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