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Chemical Compound Review:

AR-1K5362 (2S)-2-amino-6-[[3-hydroxy- 5...

Synonyms: AR-1K5363, AC1L4O3C, AC1Q5QM5, 6-Pyridoxyllysine, Epsilon-pyridoxyllysine

Gregory, J.F. et al., Morjana, N.A. et al., Gregory, J.F.

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High impact information on Epsilon-pyridoxyllysine

Spectral analysis indicated that activation by both PLP and PLP-AMP was accompanied by Schiff's base formation and epsilon-pyridoxyllysine was identified in hydrolysates of the reduced enzyme PLP-complex [1].
Effects of epsilon-pyridoxyllysine and related compounds on liver and brain pyridoxal kinase and liver pyridoxamine (pyridoxine) 5'-phosphate oxidase [2].
Rat bioassay of the PP-BSA revealed that epsilon-pyridoxyllysine exhibited 60% activity relative to the molar potency of pyridoxine [3].
These results suggest the partial release of bound vitamin B-6 possibly by in vivo enzymatic hydrolysis of epsilon-pyridoxyllysine [3].

References

Aldose reductase from human psoas muscle. Affinity labeling of an active site lysine by pyridoxal 5'-phosphate and pyridoxal 5'-diphospho-5'-adenosine. Morjana, N.A., Lyons, C., Flynn, T.G. J. Biol. Chem. (1989) [Pubmed]
Effects of epsilon-pyridoxyllysine and related compounds on liver and brain pyridoxal kinase and liver pyridoxamine (pyridoxine) 5'-phosphate oxidase. Gregory, J.F. J. Biol. Chem. (1980) [Pubmed]
Vitamin B-6 activity for rats of epsilon-pyridoxyllysine bound to dietary protein. Gregory, J.F., Kirk, J.R. J. Nutr. (1978) [Pubmed]

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