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Chemical Compound Review

GNF-PF-4337     2-phenyl-1H-quinolin-4-one

Synonyms: YT-1 Compound, CHEMBL277148, SureCN367268, AG-D-34677, SureCN1256551, ...
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Disease relevance of NSC28866

  • Suppressive effect of 2-phenyl-4-quinolone (YT-1) on hind-paw edema and cutaneous vascular plasma extravasation in mice [1].
  • 2-Phenyl-4-quinolone and 9-oxo-9,10-dihydroacridine derivatives were synthesized and screened as potential antitumor promoters by examining the ability of the compounds to inhibit Epstein-Barr virus early antigen (EBV-EA) activation induced by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) in Raji cells [2].

High impact information on NSC28866


Anatomical context of NSC28866


  1. Suppressive effect of 2-phenyl-4-quinolone (YT-1) on hind-paw edema and cutaneous vascular plasma extravasation in mice. Wang, J.P., Hsu, M.F., Raung, S.L., Kuo, S.C. Naunyn Schmiedebergs Arch. Pharmacol. (1994) [Pubmed]
  2. Cancer preventive agents, Part 2: Synthesis and evaluation of 2-phenyl-4-quinolone and 9-oxo-9,10-dihydroacridine derivatives as novel antitumor promoters. Nakamura, S., Kozuka, M., Bastow, K.F., Tokuda, H., Nishino, H., Suzuki, M., Tatsuzaki, J., Morris Natschke, S.L., Kuo, S.C., Lee, K.H. Bioorg. Med. Chem. (2005) [Pubmed]
  3. Antitumor Agents. 211. Fluorinated 2-phenyl-4-quinolone derivatives as antimitotic antitumor agents. Xia, Y., Yang, Z.Y., Xia, P., Hackl, T., Hamel, E., Mauger, A., Wu, J.H., Lee, K.H. J. Med. Chem. (2001) [Pubmed]
  4. Involvement of cyclic AMP generation in the inhibition of respiratory burst by 2-phenyl-4-quinolone (YT-1) in rat neutrophils. Wang, J.P., Raung, S.L., Huang, L.J., Kuo, S.C. Biochem. Pharmacol. (1998) [Pubmed]
  5. 2-Phenyl-4-quinolone prevents serotonin-induced increases in endothelial permeability to albumin. Lee, H.Z., Lin, W.C., Yeh, F.T., Wu, C.H. Eur. J. Pharmacol. (1998) [Pubmed]
  6. Antitumor agents. Part 226: synthesis and cytotoxicity of 2-phenyl-4-quinolone acetic acids and their esters. Xia, Y., Yang, Z.Y., Xia, P., Bastow, K.F., Nakanishi, Y., Nampoothiri, P., Hamel, E., Brossi, A., Lee, K.H. Bioorg. Med. Chem. Lett. (2003) [Pubmed]
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