Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

KST-1A2821 (2S,3R,5R,9R,10R,13R,17S)- 2,3,14...

Synonyms: KST-1A2822, AR-1A3768, AR-1A3769, AC1L4P54, A816100, ...

Grossniklaus-Bürgin, C. et al., Kayser, H. et al., Kayser, H. et al.

Kayser, Ertl, Eilinger, Spindler-Barth, Winkler, Kayser, Winkler, Spindler-Barth,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on 20,26-Dihydroxyecdysone

A microsomal cytochrome P450 from a cell line of the insect Chironomus tentans has been shown to hydroxylate the steroid hormone 20-hydroxyecdysone at C(26) to yield 20,26-dihydroxyecdysone, P1, which is further metabolized to P2 and P3 [1].
In the host hemolymph a broad peak of ecdysteroids during molting into the 4th stadium and a continuous increase from day 2 (onset of precocious wandering) until day 4 (emergence of parasitoid) were observed; 20-hydroxyecdysone and 20,26-dihydroxyecdysone were predominant [2].

Gene context of 20,26-Dihydroxyecdysone

The enzyme responsible for the synthesis of 20,26-dihydroxyecdysone in the Chironomus cell preparations has been characterized as a typical cytochrome P-450-dependent monooxygenase [3].

References

Diastereomeric ecdysteroids with a cyclic hemiacetal in the side chain produced by cytochrome P450 in hormonally resistant insect cells. Kayser, H., Ertl, P., Eilinger, P., Spindler-Barth, M., Winkler, T. Arch. Biochem. Biophys. (2002) [Pubmed]
Endocrine interrelationship between the parasitoid Chelonus sp. and its host Trichoplusia ni. Grossniklaus-Bürgin, C., Lanzrein, B. Arch. Insect Biochem. Physiol. (1990) [Pubmed]
26-hydroxylation of ecdysteroids is catalyzed by a typical cytochrome P-450-dependent oxidase and related to ecdysteroid resistance in an insect cell line. Kayser, H., Winkler, T., Spindler-Barth, M. Eur. J. Biochem. (1997) [Pubmed]

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