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Chemical Compound Review:

AG-D-08789 2-amino-6-(1,2,3- trihydroxypropyl)-5,6,7,8...

Synonyms: HMDB00942, AC1Q6INH, CTK4A0026, AR-1D8542, AR-1D8543, ...

Iizuka, H. et al., Sawada, M. et al., Adler, C. et al., Kurobane, T. et al., Takimoto, E. et al., et al.

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Disease relevance of Tetrahydroneopterin

Protective effects of 5,6,7,8-tetrahydroneopterin against X-ray radiation injury in mice [1].

High impact information on Tetrahydroneopterin

Mice given the antioxidant tetrahydroneopterin as a control did not display changes in TAC response [2].
(6R)-BPH4 (the naturally occurring form) at 42 microM, tetrahydroneopterin at 50 microM, and 6-methyltetrahydropterin at 100 microM increased tryptophan hydroxylase activity to 350, 145, and 146% of control values, respectively [3].
Tetrahydroneopterin and 6-hydroxymethyltetrahydropterin also are converted to their corresponding 7-substituted isomers and serve as cofactors in the phenylalanine hydroxylase reaction [4].
Effect of 5,6,7,8-tetrahydroneopterin on oxidative modification of low-density lipoprotein, and its uptake in the macrophage-like cell line J774 [5].
Since oxidative modification of low-density lipoprotein (LDL) and uptake of the oxidized LDL by macrophages are closely related to the pathogenesis of atherosclerosis, we examined the inhibitory effect of 5,6,7,8-tetrahydroneopterin (NPH4) on Cu(II)-induced lipid peroxidation of LDL [5].

Associations of Tetrahydroneopterin with other chemical compounds

Previously, we have reported that 5,6,7,8-tetrahydroneopterin (NPH4), a reduced form of neopterin, possesses an antioxidant activity in various systems [6].

References

Protective effects of 5,6,7,8-tetrahydroneopterin against X-ray radiation injury in mice. Yasumura, M., Morimoto, T., Takagi, M., Hirose, H., Taguchi, O. Biochim. Biophys. Acta (1999) [Pubmed]
Oxidant stress from nitric oxide synthase-3 uncoupling stimulates cardiac pathologic remodeling from chronic pressure load. Takimoto, E., Champion, H.C., Li, M., Ren, S., Rodriguez, E.R., Tavazzi, B., Lazzarino, G., Paolocci, N., Gabrielson, K.L., Wang, Y., Kass, D.A. J. Clin. Invest. (2005) [Pubmed]
(6R)-tetrahydrobiopterin increases the activity of tryptophan hydroxylase in rat raphe slices. Sawada, M., Sugimoto, T., Matsuura, S., Nagatsu, T. J. Neurochem. (1986) [Pubmed]
7-substituted pterins in humans with suspected pterin-4a-carbinolamine dehydratase deficiency. Mechanism of formation via non-enzymatic transformation from 6-substituted pterins. Adler, C., Ghisla, S., Rebrin, I., Haavik, J., Heizmann, C.W., Blau, N., Kuster, T., Curtius, H.C. Eur. J. Biochem. (1992) [Pubmed]
Effect of 5,6,7,8-tetrahydroneopterin on oxidative modification of low-density lipoprotein, and its uptake in the macrophage-like cell line J774. Iizuka, H., Watanabe, Y., Kojima, S. Jpn. J. Pharmacol. (1996) [Pubmed]
Effect of 5,6,7,8-tetrahydroneopterin on the bovine endothelial cell injury induced by cumene hydroperoxide. Kurobane, T., Kojima, S., Yoshimura, M., Icho, T., Kajiwara, Y., Kubota, K. Jpn. J. Pharmacol. (1995) [Pubmed]

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